Publications by authors named "M Kolar"
Wound healing represents a complex and evolutionarily conserved process across vertebrates, encompassing a series of life-rescuing events. The healing process runs in three main phases: inflammation, proliferation, and maturation/remodelling. While acute inflammation is indispensable for cleansing the wound, removing infection, and eliminating dead tissue characterised by the prevalence of neutrophils, the proliferation phase is characterised by transition into the inflammatory cell profile, shifting towards the prevalence of macrophages.
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- Liquid-liquid phase separation in the cell nucleus plays a key role in gene regulation, chromatin organization, and DNA repair processes.
- The study utilized lipid-interacting RNA sequencing (LIPRNAseq) and confocal microscopy to explore the interaction of phosphatidylinositol 4,5 bisphosphate (PIP2) with specific RNA, identifying a PIP2-binding RNA motif and its colocalization with long non-coding RNA HANR in the perinucleolar compartment.
- The findings suggest a link between PIP2, lncHANR, and oncogenic super-enhancers, indicating their potential as prognostic markers for cancer and highlighting the importance of understanding lipid metabolism and RNA interactions for future cancer treatment strategies.
Article Synopsis
- The study investigates the phylogenetic relationships of two morphologically similar fungal genera within the Sordariomycetes, confirming they are congeneric and proposing new combinations for their classification.
- New species were identified through molecular data, particularly using specific gene markers, as traditional morphology was insufficient for distinguishing them.
- The research highlights the importance of the ascogenous system for genus identification and discusses the global diversity and biogeography of the genera, including the publication of whole-genome analyses to improve taxonomic standards.
Nanostructured materials with antibacterial activity face the same threat as conventional antibiotics - bacterial resistance, which reduces their effectiveness. However, unlike antibiotics, research into the emergence and mechanisms of bacterial resistance to antibacterial nanomaterials is still in its early stages. Here we show how Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli bacteria develop resistance to silver nanoparticles, resulting in an increase in the minimum inhibitory concentration from 1.
View Article and Find Full Text PDFThree Stages of Nascent Protein Translocation Through the Ribosome Exit Tunnel.
Wiley Interdiscip Rev RNA
November 2024
Article Synopsis
- All proteins are created in ribosomes through a process called translation, which involves four main stages: initiation, elongation, termination, and recycling.
- Peptide bonds are formed during the elongation phase, where transfer RNAs bring amino acids to the ribosome to build the protein one unit at a time.
- The text breaks down the lifetime of a nascent polypeptide in the ribosome into three stages, discussing how external forces affect the polypeptide's movement and interaction with the ribosome, highlighting gaps in current research on protein synthesis.