Publications by authors named "M Kodani"
Article Synopsis
- The study investigates the effectiveness of immune checkpoint inhibitors (ICI) for non-small cell lung cancer (NSCLC) patients, particularly comparing those with brain metastases (BM) to those without.
- It analyzes data from 240 patients, finding no major overall survival differences between the two groups, but identifies a significant survival disadvantage for patients with BM among those with high PD-L1 expression (≥50%).
- The conclusion suggests that while ICI is generally effective for both groups, patients with BM and high PD-L1 levels may have poorer outcomes compared to their counterparts without BM.
Article Synopsis
- Brigatinib is a next-generation TKI that targets ROS1 and was evaluated in a phase II study called the Barossa study for patients with ROS1-rearranged solid tumors, dividing participants into three cohorts based on their treatment history.
- The study included 51 patients, primarily with ROS1-rearranged NSCLC; cohort 1 saw a 71.4% response rate in TKI-naive patients, while cohort 2 had a 31.6% response rate for those previously treated with crizotinib.
- Overall, while brigatinib showed efficacy, especially in cohort 1, it did not produce any responses in patients with other solid tumors in cohort 3, and the safety profile was consistent with earlier
Following the fertilization of an egg by a single sperm, the egg coat or zona pellucida (ZP) hardens and polyspermy is irreversibly blocked. These events are associated with the cleavage of the N-terminal region (NTR) of glycoprotein ZP2, a major subunit of ZP filaments. ZP2 processing is thought to inactivate sperm binding to the ZP, but its molecular consequences and connection with ZP hardening are unknown.
View Article and Find Full Text PDFPurpose: Immune checkpoint inhibitors (ICIs) are ineffective against epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC). This study aimed to investigate the clinical characteristics of patients who were treated or not treated with ICIs, and of those who benefit from immunotherapy in EGFR-mutant NSCLC.
Methods: We analyzed patients with unresectable stage III/IV or recurrent NSCLC harboring EGFR mutations using a prospective umbrella-type lung cancer registry (CS-Lung-003).
In mammals, females undergo reproductive cessation with age, whereas male fertility gradually declines but persists almost throughout life. However, the detailed effects of ageing on germ cells during and after spermatogenesis, in the testis and epididymis, respectively, remain unclear. Here we comprehensively examined the in vivo male fertility and the overall organization of the testis and epididymis with age, focusing on spermatogenesis, and sperm function and fertility, in mice.
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