Publications by authors named "M Kodanda Ram"
Background: Multiple myeloma (MM) is a hematological malignancy characterized by the clonal proliferation of malignant plasma cells within the bone marrow. The disease's complexity is underpinned by a variety of genetic and molecular abnormalities that drive its progression.
Methods: This review was conducted through a state-of-The-art literature search, primarily utilizing PubMed to gather peer-reviewed articles.
Hyperglycemia, a key characteristic of type 2 diabetes mellitus (T2DM), highlights the need for effective management strategies. This study aims to analyze the impact of multistrain probiotic supplementation on glycemic control in T2DM patients. During a 24-week randomized controlled trial involving 130 participants, subjects were assigned to either a probiotic group or a placebo group.
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- First-degree relatives of multiple myeloma patients have a higher risk for the disease, yet the role of genetic variants in hereditary cancer genes remains unclear.
- A study analyzed germline exomes from nearly 1,700 multiple myeloma patients, identifying pathogenic variants in about 8.6-11.5% of cases, particularly in DNA repair genes like BRCA1 and BRCA2.
- The findings suggest that around 10% of multiple myeloma patients may have an undiagnosed cancer predisposition syndrome, indicating the importance of considering genetic testing for younger patients or those with a family cancer history to inform treatment options.