Publications by authors named "M Kock"
Genomic Epidemiology of Pseudomonas aeruginosa Sequence Type 111.
Eur J Clin Microbiol Infect Dis
December 2024
Article Synopsis
- Pseudomonas aeruginosa ST111 is a global multidrug-resistant strain causing bloodstream infections, and there's limited understanding of its molecular epidemiology in Canada.
- Researchers characterized Canadian ST111 strains collected between 2010-2018 using whole genome sequencing and studied their global evolutionary relationships.
- The study identified three main clades (A, B, C) and two subclades (C1, C2), revealing that clade C2 dominates globally and that serotype switching and genetic element acquisition are significant factors in its evolution.
Objectives: Clostridioides difficile infection is a serious healthcare-associated infection linked to antimicrobial use. The severity of the disease can be associated with hypervirulent ribotypes such as RT027. The study aimed to investigate the molecular epidemiology and genomic characteristics of C.
View Article and Find Full Text PDFKlebsiella pneumoniae multidrug-resistant (MDR) high-risk clones drive the spread of antimicrobial resistance (AMR) associated infections, resulting in limited therapeutic options. This study described the genomic characteristics of K. pneumoniae MDR high-risk clones in Gauteng, South Africa.
View Article and Find Full Text PDFObjectives: Health state utility (HSU) instruments for calculating quality-adjusted life years, such as the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Utility - Core 10 Dimensions (QLU-C10D), derived from the EORTC QLQ-30 questionnaire, the Patient-Reported Outcome Measurement Information System (PROMIS) preference score (PROPr), and the EuroQoL-5-Dimensions-5-Levels (EQ-5D-5L), yield different HSU values due to different modeling and different underlying descriptive scales. For example the QLU-C10D includes cancer-relevant dimensions such as nausea. This study aimed to investigate how these differences in descriptive scales contribute to differences in HSU scores by comparing scores of cancer patients receiving chemotherapy to those of the general population.
View Article and Find Full Text PDFObjective: This study aimed to investigate the presence of ESKAPE organisms on the hands of students working in the intensive care unit (ICU) at a veterinary academic hospital.
Methods: A cross-sectional study was conducted among students working in an ICU at a veterinary academic hospital in South Africa. Students were sampled before the start of the ICU shift using a modified glove-juice method.