Publications by authors named "M Knott"
Background: Medical narratives are fundamental to the correct identification of a patient's health condition. This is not only because it describes the patient's situation. It also contains relevant information about the patient's context and health state evolution.
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- The study investigates the effectiveness and safety of laser interstitial thermal therapy (LITT) for treating newly diagnosed glioblastoma (nGBM) in patients with large-volume, deep-seated tumors, addressing a gap in existing research.
- Researchers conducted a retrospective analysis comparing outcomes between patients with tumor volumes of 10 cm³ or greater and those with volumes less than 10 cm³, focusing on survival and complications post-treatment.
- Results indicated no significant differences in hospital stay, complications, or overall survival between the two groups, suggesting that tumor volume may not significantly influence the success of LITT for deep-seated nGBM cases.
Sex differences in immune responses impact cancer outcomes and treatment response, including in glioblastoma (GBM). However, host factors underlying sex specific immune-cancer interactions are poorly understood. Here, we identify the neurotransmitter γ-aminobutyric acid (GABA) as a driver of GBM-promoting immune response in females.
View Article and Find Full Text PDFBackground: Endovascular thrombectomy (EVT) has been proven effective in anterior circulation stroke due to large vessel occlusion (LVO). However, translation from randomized clinical trials (RCTs) with highly selected patients to real-world requires confirmation, particularly to identify associations outside of strict selection criteria.
Aims: This study aims to compare functional outcomes after EVT in real-world with those reported in RCTs, and to identify associations with functional outcome after EVT outside RCT-criteria.
Objective: Postconcussive symptom questionnaires (PCSQs) are often used in concussion patient assessment, yet there is a lack of knowledge as to whether symptom subtype prevalence is dependent on the mechanism of injury (MOI). These subtypes can be defined as cognitive, atlanto-occipital/cervical spine, autonomic, balance, low energy/fatigue/sleep, emotional changes, eyes, and somatic. Using an institutional PCSQ that quantitatively addressed these subtypes, this retrospective study aimed to provide insight into differences in subtype symptomatology between sports-related (SR) and non-sports-related (NSR) injuries.
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