Publications by authors named "M Kmetova-Sivonova"
Article Synopsis
- * The study identified 22 proteins with altered levels in heart homogenates of rats with chronic mild HHcy, highlighting their roles in energy metabolism, cardiac function, stress response, and antioxidant defense.
- * Findings showed decreased antioxidant defenses and increased oxidative damage, suggesting that both altered protein expression and oxidative stress contribute to heart damage in HHcy.
Article Synopsis
- The study investigated the role of three cytochrome P450 1A2 polymorphisms (rs2472299, rs2470890, and rs11072508) in prostate cancer risk and progression using a case-control design with 522 patients and 554 healthy controls.
- While rs2472299 and rs11072508 showed no significant association with prostate cancer risk, rs2470890 exhibited a decreased risk of prostate cancer and was linked to higher Gleason scores, suggesting it might influence disease severity.
- Additionally, haplotype analysis indicated that common variants like 'GTT' and 'ACC' were associated with advanced disease stages and Gleason scores, highlighting their potential role in predicting cancer progression.
Pyruvate carboxylase (PC) is a mitochondrial enzyme catalyzing the ATP-dependent reaction of pyruvate prolongation with bicarbonate ion to oxaloacetate. The synthesis of oxaloacetate by PC, an intermediate of the Krebs cycle, is recently recognized as a significant anaplerotic reaction that supports the biosynthetic capability, growth, aggressiveness, and even viability of several cancer cell types. PC expression was confirmed in several types of cancer cells and tumors.
View Article and Find Full Text PDFIncreased concentration of plasma homocysteine (Hcy) is an independent risk factor of cardiovascular disease, yet the mechanism by which hyperhomocysteinemia (HHcy) causes cardiac dysfunction is largely unknown. The aim of present study was to investigate the contribution of sarcoplasmic reticulum to impaired cardiac contractile function in HHCy. HHcy-induced by subcutaneous injection of Hcy (0.
View Article and Find Full Text PDFOncoproteomic technologies offer a complementary approach to the understanding of cancer proteins' function and the translation of molecular knowledge into clinical practice. Our aim was to compare the proteomic profiles of prostate tumors versus benign prostatic hyperplasia (BPH) tissues in order to identify modulated proteins as the potential biomarkers for prostate cancer. Proteins extracted from twenty prostate cancer tissue specimens and ten BPH tissues were analyzed by two-dimensional electrophoresis (2-DE) coupled with MALDI-TOF mass spectrometry.
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