Publications by authors named "M Klok"
Objectives: Depression and ADHD often co-occur and are both characterized by altered attentional processing. Differences and overlap in the profile of attention to emotional information may help explain the co-occurence. We examined negative attention bias in ADHD as neurocognitive marker for comorbid depression.
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- The study highlights the crucial role of molecule self-replication and folding in the origins of life, revealing how specific interactions lead to the formation of stable structures.
- It showcases a synthetic chemical system where complex molecules, called foldamers and self-replicating assemblies, form selectively from simpler building blocks due to noncovalent interactions.
- The findings suggest that the transition between foldamers and replicators is influenced more by the type of interactions—whether they occur within the same molecule or between different ones—than by the chemical nature of the building blocks themselves.
Background: Major depressive disorder (MDD) has been related to structural brain characteristics that are correlated with the severity of disease. However, the correlation of these structural changes is less well clarified in treatment-resistant depression (TRD).
Aims: To summarise the existing literature on structural brain characteristics in TRD to create an overview of known abnormalities of the brain in patients with MDD, to form hypotheses about the absence or existence of a common pathophysiology of MDD and TRD.
Freezing of gait and major depressive disorder responding both to electroconvulsive therapy.
Parkinsonism Relat Disord
September 2019
Objective: We aimed to study the occurrence and development of axonal pathology and the influence of astrocytes in vanishing white matter.
Methods: Axons and myelin were analyzed using electron microscopy and immunohistochemistry on and single- and double-mutant mice and patient brain tissue. In addition, astrocyte-forebrain co-culture studies were performed.