Publications by authors named "M Kleppe"
Article Synopsis
- Lysine-specific demethylase 1 (LSD1) plays a key role in the progression of metastatic castration-resistant prostate cancer (mCRPC), particularly in its neuroendocrine form (NEPC), highlighting the need for effective LSD1 inhibitors like bomedemstat for treating these cancers.
- Bomedemstat was evaluated using various scientific methods, showing it is an irreversible inhibitor of LSD1 with significantly higher specificity over monoamine oxidase enzymes, and it effectively reduces tumor growth in prostate cancer models.
- The study found that bomedemstat accumulates well in tumors after oral administration and has an overall tolerable safety profile with manageable side effects, supporting its clinical
Article Synopsis
- Lysine-specific demethylase 1 (LSD1) plays a crucial role in tumor progression in metastatic castration-resistant prostate cancer (mCRPC), particularly in the aggressive neuroendocrine subtype (NEPC) that shows resistance to typical therapies.* -
- The study found that elevated LSD1 levels in NEPC correlate with poor clinical outcomes, and using the LSD1 inhibitor bomedemstat resulted in significant tumor regression in various cancer models.* -
- Mechanistically, LSD1 inhibition was shown to disrupt key interactions that suppress a neuronal transcriptional program, highlighting the potential of LSD1 inhibitors as a promising treatment strategy for aggressive mCRPC types.*
Objective: A new guideline on population-screening cervical cytology was introduced to improve diagnosis and management of (pre-)malignant cervical lesions. Subsequently, more colposcopies and more large loop excision of the transformation zone (LLETZ) were performed. There is little information about the relevance of positive margins for cervical intraepithelial neoplasia (CIN) after LLETZ.
View Article and Find Full Text PDFMonoclonal antibody (mAb) drug products (DP) for IV administration are commonly diluted in a diluent such 0.9% sodium chloride (saline) or 5% dextrose (D5W) injection yielding IV admixtures before infusion or injection. During dose preparation, storage, and administration, the sterility of IV admixtures must be maintained to ensure patient safety.
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