Publications by authors named "M Kitaichi"
Article Synopsis
- Current treatments for major depressive disorder struggle with low success rates and complications from symptoms like psychosis, while serotonin neurotransmission is an important focus for new drug targets.
- This study investigates DSP-6745, a new serotonin modulator, and its effects on depression and related symptoms.
- Results show that DSP-6745 acts as a potent serotonin transporter inhibitor and enhances neurotransmitter release, leading to rapid antidepressant-like effects and improvements in anxiety and cognitive function in animal tests.*
Article Synopsis
- * The study identifies mutations in the nAChR subunit Dα5 that can restore normal function in a specific secretory matrix protein associated with cholinergic synapses in the brain.
- * Results suggest that Dα5 reduces synaptic nAChR levels through internalization, and Hig protein prevents this process by anchoring Dα5 to the synaptic cleft matrix.
The presence of emphysema is relatively common in patients with fibrotic interstitial lung disease. This has been designated combined pulmonary fibrosis and emphysema (CPFE). The lack of consensus over definitions and diagnostic criteria has limited CPFE research.
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- - This guideline focuses on the diagnosis of hypersensitivity pneumonitis (HP) and was created by a collaboration of multiple respiratory societies, using systematic reviews and expert consensus to develop recommendations.
- - HP is classified into two types: nonfibrotic and fibrotic, with specific diagnostic features and testing methods recommended for both, including serum IgG testing and bronchoalveolar lavage.
- - The committee emphasized the importance of a detailed patient history and suggested further research to fill existing knowledge gaps, proposing a systematic approach to diagnosing HP that will be updated as new information emerges.
In 2011, a new classification of lung adenocarcinoma was published. Since then there have been multiple studies regarding observer variability in predominant subtype determination, with levels of agreement generally in the weak to moderate range. In the 2011 and subsequent WHO 2015 classification, a recommendation was also made to visually assess and record the percentage of each subtype in 5% increments.
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