To what extent do children's expressions of time actually refer to time? An investigation into the temporal and discursive usages of temporal adverbs in family interaction.

Many studies have explored children's acquisition of temporal adverbs. However, the extent to which children's early temporal language has discursive instead of solely temporal meanings has been largely ignored. We report two corpus-based studies that investigated temporal adverbs in Finnish child-parent interaction between the children's ages of 1;7 and 4;11.

Mixing energy as an adjustment tool for aerodynamic behaviour of an inhaled product: In-vitro and in-vivo effects.

This paper describes the development of a fixed dose dry powder combination of indacaterol maleate (Inda) and glycopyrronium bromide (Glyco) in Easyhaler® inhaler for a comparative pharmacokinetic (PK) study, as well as the outcome of such a study. The development aim was to produce formulations with three different in vitro dispersibility profiles for both Inda and Glyco. This so-called 'rake' approach allows for quantitation of the candidate formulations relative to the reference product Ultibro® Breezhaler® in terms of the key PK parameters.

Can filled pauses be represented as linguistic items? Investigating the effect of exposure on the perception and production of .

The current paper presents three studies that investigated the effect of exposure on the mental representations of filled pauses (). In Study 1, a corpus analysis identified the frequency of co-occurrence of filled pauses with words located immediately before or after them in naturalistic spoken adult British English (BNC2014). Based on the collocations identified in Study 1, in Study 2, 22 native British English-speaking adults heard sentences in which the location of filled pauses and the co-occurring words were manipulated and the participants were asked to judge the acceptability of the sentences heard.

The Effect of Language-Specific Characteristics on English and Japanese Speakers' Ability to Recall Number Information.

The current paper presents two experiments investigating the effect of presence versus absence of compulsory number marking in a native language on a speaker's ability to recall number information from photos. In Experiment 1, monolingual English and Japanese adults were shown a sequence of 110 photos after which they were asked questions about the photos. We found that the English participants showed a significantly higher accuracy rate for questions testing recall for number information when the correct answer was "2" (instead of "1") than Japanese participants.

Pharmacokinetics of Salmeterol and Fluticasone Propionate Delivered in Combination via Easyhaler and Diskus Dry Powder Inhalers in Healthy Subjects.

Background: Easyhaler dry powder inhaler (DPI) containing salmeterol and fluticasone propionate was developed for the treatment of asthma and chronic obstructive pulmonary disease. Three different Salmeterol/fluticasone Easyhaler test products (Orion Pharma, Finland) were compared against the reference product Seretide Diskus DPI (GlaxoSmithKline, United Kingdom) to study whether any of the test products are bioequivalent with the reference.

Methods: Open and randomized pharmacokinetic four-period crossover study on 65 healthy volunteers was performed in a single center to compare the lung deposition and total systemic exposure of salmeterol and fluticasone propionate after administration of single doses (two inhalations of 50/500 μg/inhalation strength) in fasting conditions.