Publications by authors named "M Kirinoki"
The WHO considers schistosomiasis, which is controlled by the mass administration of the drug praziquantel (PZQ), to be a neglected tropical disease. Despite its clinical use for over four decades, PZQ remains the only choice of chemotherapy against this disease. Regarding the previous studies that demonstrated that PZQ activates the transient receptor potential (TRP) channel in Schistosoma mansoni (Sm.
View Article and Find Full Text PDFAsian schistosomiasis caused by the blood fluke is endemic in northern Cambodia and Southern Lao People's Democratic Republic. The disease is mainly diagnosed by stool microscopy. However, serodiagnosis such as enzyme-linked immunosorbent assay (ELISA) with soluble egg antigen (SEA), has been shown to have better sensitivity compared to the stool examination, especially in the settings with a low intensity of infection.
View Article and Find Full Text PDFArticle Synopsis
- A blood fluke causing schistosomiasis is found near the Mekong River, and control efforts like drug administration have reduced its prevalence but compromised traditional diagnostic methods.
- Researchers developed a new serological test using a specific protein (rSmekTPx-1) to improve the diagnosis of human schistosomiasis compared to the standard Kato-Katz method.
- The new test showed higher sensitivity (89.3%) and specificity (93.3%) compared to an older method (rSjTPx-1), indicating it may be a better option for detecting current infections.
Host-derived microRNAs (miRNAs) play important regulatory roles in schistosomiasis-induced hepatic fibrosis. This study analyzed selected serum miRNAs among Filipino schistosomiasis japonica patients with ultrasound (US)-detectable hepatic fibrosis. A prospective cohort study design with convenience sampling was employed from 2017 to 2019.
View Article and Find Full Text PDFDiagnostic Performance of Parasitological, Immunological, Molecular, and Ultrasonographic Tests in Diagnosing Intestinal Schistosomiasis in Fieldworkers From Endemic Municipalities in the Philippines.
Front Immunol
July 2022
Schistosomiasis remains to ha/ve a significant public health impact in the Philippines. The Kato-Katz (K-K) technique is the reference standard and most used technique for definitive diagnosis of intestinal schistosomiasis for control programs in endemic regions. However, this has a very low sensitivity when applied in areas of low endemicity and patients with light infection.
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