Parametric uncertainties and influence of the dead volume representation in modelling simulated moving bed separation processes.

In this study, a systematic numerical procedure for identifying the model parameters of simulated moving bed (SMB) separation processes is developed. The parameters are first estimated by minimizing a weighted least-squares criterion using experimental data from batch experiments, e.g.

A complete procedure for leak detection and diagnosis in a complex heat exchanger using data-driven fuzzy models.

In this paper, an efficient fuzzy model-based leak detection algorithm is designed for a pilot heat exchanger. A dynamic fuzzy model of the physical plant is first derived from input-output measurements using a fuzzy clustering technique. This model is run in parallel to the process for symptom generation.

Principles of a competitive binding assay for the study of the interactions of poorly water-soluble ligands with their soluble binding partners. Application to bilirubin with the use of Sephadex G-10 as a competitive adsorbent.

1. A generally applicable method is described for obtaining experimental data on the interactions between a poorly water-soluble ligand and soluble binding factors, with the use of chemically inert solid adsorbent. The equilibrium distribution of the ligand between the liquid phase containing the soluble binders and the adsorbent must be measured and knowledge of the binding isotherm of the adsorbent is required.