Publications by authors named "M Kinkhabwala"
Background : Incidence of hepatocellular cancer (HCC) in the Bronx is 61% higher than the rest of New York State. Underserved populations are not well represented in clinical trials of immune checkpoint inhibitors (ICI).
Methods: Demographics were tabulated for 194 patients treated with ICI at the Montefiore-Einstein Comprehensive Cancer Center (MECCC) between 2017 and 2022.
Article Synopsis
- - Technetium-labeled radiotracers like Tc-99m PYP are used to diagnose transthyretin cardiac amyloidosis (ATTR-CA), but the significance of its uptake outside the heart (extracardiac uptake) is not well understood.
- - In the SCAN-MP study, primarily involving Black and Hispanic participants over 60 with heart failure, researchers found that 11.1% of subjects had extracardiac Tc-99m PYP uptake, with kidney and bone uptake being the most common.
- - Despite the discovery of extracardiac uptake in these participants, only 1.1% had findings that were clinically actionable, indicating that most of the uptake was not significant for further
Article Synopsis
- The study investigates the best heart-to-contralateral chest (H/CL) ratio threshold for diagnosing transthyretin cardiac amyloidosis (ATTR-CA) using Tc pyrophosphate (PYP) imaging in older adults with heart failure.
- Among 229 patients, only 14 confirmed cases of ATTR-CA were identified, and most scans showed no PYP uptake, highlighting the challenge of accurate diagnosis.
- An H/CL threshold of ≥ 1.4 provided high specificity and positive predictive value, but a lower threshold of ≥ 1.3 had higher sensitivity, indicating that using these thresholds in low pretest probability populations could lead to misclassifications.
Lice are parasitic infections that can infect humans and survive by consuming host blood. They are most commonly associated with a lack of hygiene and occur most commonly in school-age children, homeless populations, and densely populated areas. Lice infections can potentially lead to vector-containing illness and are rarely complicated by acute blood loss anemia.
View Article and Find Full Text PDFImportance: Ischemic cold storage (ICS) of livers for transplant is associated with serious posttransplant complications and underuse of liver allografts.
Objective: To determine whether portable normothermic machine perfusion preservation of livers obtained from deceased donors using the Organ Care System (OCS) Liver ameliorates early allograft dysfunction (EAD) and ischemic biliary complications (IBCs).
Design, Setting, And Participants: This multicenter randomized clinical trial (International Randomized Trial to Evaluate the Effectiveness of the Portable Organ Care System Liver for Preserving and Assessing Donor Livers for Transplantation) was conducted between November 2016 and October 2019 at 20 US liver transplant programs.