Publications by authors named "M Kimmig"
Article Synopsis
- PD-1-based immune checkpoint inhibitors are key treatments for melanoma, and tumor PD-L1 expression is a crucial biomarker for predicting therapy success.
- This study analyzed PD-L1 levels from various tumor tissues, including primary tumors and metastases, from 448 patients who received treatment between 2014 and 2020, comparing their correlation with treatment outcomes like best overall response and survival rates.
- Results showed that PD-L1 positivity in lymph node metastases was significantly associated with better treatment responses and overall survival, while primary tumors and skin/subcutaneous metastases showed weaker correlations.
Article Synopsis
- Immunotherapy using the grass tablet Grazax is effective for reducing symptoms of grass pollen-induced rhinoconjunctivitis and asthma in children aged 5 to 16.
- The study involved 253 children who received either the active treatment or a placebo, with significant improvements in symptom scores for those receiving Grazax.
- The treatment was generally well tolerated, though some patients experienced mild adverse reactions, such as oral itching.
A comprehensive classification of midfacial/craniofacial fractures, based on two- and three-dimensional computed tomography (2D and 3D-CT) is presented. We performed a postmortem analysis of 24 patients who had died from trauma with signs of craniofacial fractures, based on 2D and 3D-CT studies with pathoanatomical findings. In addition, CT findings for 100 patients with craniofacial injuries requiring an emergency CT were correlated with surgical findings and follow-up results.
View Article and Find Full Text PDFOsteopontin (OPN) is a chemotactic protein that attracts immune cells, to inflammatory sites. The sensitization phase of allergic cutaneous contact hypersensitivity (CHS) requires the migration of Langerhans cells/dendritic cells (LCs/DCs) from skin to draining lymph nodes. Characterizing OPN function for LC/DC migration we found upregulated OPN expression in hapten sensitized skin and draining lymph nodes.
View Article and Find Full Text PDFObjective: To evaluate the influence of different spiral CT examination protocols suitable for clinical use on image quality and to assess the observer dependence in interactive real-time virtual bronchoscopy.
Methods And Patients: Real-time perspective volume rendering of the airways in twenty normal patients based on four different spiral CT examination protocols was evaluated by four observers in regard to the order of depictable bronchi.
Results: Best results were obtained using an examination protocol with a small beam collimation and a maximum pitch.