Publications by authors named "M Killer"
Article Synopsis
- PHT1 is a histidine/oligopeptide transporter that plays a crucial role in immune responses by interacting with the adaptor protein TASL, leading to type I interferon production.
- Chronic activation of this pathway is linked to systemic lupus erythematosus (SLE), highlighting the importance of understanding the PHT1-TASL interaction for developing treatments for autoimmune diseases.
- The study presents the Cryo-EM structure of PHT1 and suggests a model for the PHT1-TASL complex, where the first 16 residues of TASL form a helix that interacts with PHT1, providing insights into their functional relationship in immune signaling.
Article Synopsis
- Proton-dependent oligopeptide transporters (POTs) play a key role in absorbing various dietary peptides and drugs, but understanding how they transport these different substrates has been a challenge.
- Researchers presented 14 X-ray structures of the bacterial POT DtpB with diverse di- and tripeptides, revealing important information about the transporter's flexible binding site.
- By studying binding affinities of over 80 peptides and using advanced techniques like molecular docking and machine learning, they found that peptides with compact hydrophobic residues are most effectively recognized by DtpB.
Proton-coupled Oligopeptide Transporters (POTs) of the Major Facilitator Superfamily (MFS) mediate the uptake of short di- and tripeptides in all phyla of life. POTs are thought to constitute the most promiscuous class of MFS transporters, with the potential to transport more than 8400 unique substrates. Over the past two decades, transport assays and biophysical studies have shown that various orthologues and paralogues display differences in substrate selectivity.
View Article and Find Full Text PDFThe uptake of peptides in mammals plays a crucial role in nutrition and inflammatory diseases. This process is mediated by promiscuous transporters of the solute carrier family 15, which form part of the major facilitator superfamily. Besides the uptake of short peptides, peptide transporter 1 (PepT1) is a highly abundant drug transporter in the intestine and represents a major route for oral drug delivery.
View Article and Find Full Text PDFBackground: We aim to evaluate the speed and rates of reperfusion in tandem large vessel occlusion acute stroke patients undergoing upfront cervical lesion treatment (Neck-First: angioplasty and/or stent before thrombectomy) as compared to direct intracranial occlusion therapy (Head-First) in a large international multicenter cohort.
Methods: The Thrombectomy In TANdem Lesions (TITAN) collaboration pooled individual data of prospectively collected thrombectomy international databases for all consecutive anterior circulation tandem patients who underwent emergent thrombectomy. The co-primary outcome measures were rates of successful reperfusion (modified Thrombolysis in Cerebral Infarction 2b/3) and time from groin puncture to successful reperfusion.