Publications by authors named "M Kian"
Osteochondral defects (OCDs) in synovial joints are caused by trauma or inflammatory joint diseases, with no definitive treatment available. This study examined the effects of resveratrol and chondrocyte injections in a rat model of OCD. Twenty-four male Sprague-Dawley rats were divided into four groups: a control group, a resveratrol-only group (10 mg/kg), a chondrocyte-only group (1 × 10 cells), and a combined treatment group that received both treatments.
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- The study investigated the effectiveness of a PLGA scaffold combined with nanohydroxyapatite and curcumin, loaded with adipose-derived stem cells, for healing mandibular bone defects in rats.
- Forty rats were assigned to five treatment groups, and after 8 weeks, bone healing was evaluated through histomorphometry and mechanical tests, revealing significant improvements in the group treated with both stem cells and curcumin.
- Results indicated that the bioengineered scaffold showed good porosity and healing properties, suggesting its potential for bone defect treatments, but further research is required in larger animal models to fully explore its therapeutic benefits.
Introduction: Flexor tendon injuries are common and require surgery. Acellular dermal matrix (ADM) is a natural graft used to repair tissues, though infections represent the primary cause of its therapeutic failure. In this study, zinc oxide nanoparticles (ZnO-NPs) were coated on the ADM in order to add antibacterial potential as well as enhance healing properties.
View Article and Find Full Text PDFBackground: Mesenchymal stem cell (MSC) therapy has ameliorative effects for treating knee osteoarthritis (KOA) disease. Moreover, there is a growing interest in using MSCs-derived secretome (Sec) containing trophic factors secreted by MSCs for KOA treatment. Recently, some studies have suggested that the combination of MSCs and Sec has the potential to treat the diseases.
View Article and Find Full Text PDFObjectives: In the present study, we evaluated the effect of a nanofibrous scaffold including polycaprolactone (PCL), chitosan (CHT), and bentonite nanoparticles (Ben-NPS) on wound healing in order to introduce a novel dressing for burn wounds.
Materials And Methods: PCL, PCL/CHT, and PCL/CHT/Ben-NPS nanofibrous scaffolds were fabricated by the electrospinning technique. Their structural and physiochemical characteristics were investigated by Fourier-transform infrared spectroscopy (FTIR) analysis, scanning electron microscopy (SEM), tensile strength, water contact angle, as well as, swelling and degradation profiles test.