Publications by authors named "M Khodoun"
Importance of mast cell histamine secretion in IgG-mediated systemic anaphylaxis.
J Allergy Clin Immunol
November 2024
Article Synopsis
- IgG can trigger systemic anaphylaxis (SA) in both mice and humans, but the roles of mast cells and histamine in this process are still debated, especially in humans.
- In experiments with various mouse strains, it was found that histamine from connective tissue mast cells (CTMCs) is crucial for IgG-mediated anaphylaxis, particularly in young mice.
- The study concludes that the dependence on histamine for anaphylaxis varies based on factors like mouse age, sex, and immune history, suggesting complexity in how IgG-mediated SA operates in different contexts.
Proton therapy (PT) is emerging as an effective and less toxic alternative to conventional X-ray-based photon therapy (XRT) for patients with advanced head and neck squamous cell carcinomas (HNSCCs) owing to its clustered dose deposition dosimetric characteristics. For optimal efficacy, cancer therapies, including PT, must elicit a robust anti-tumor response by effector and cytotoxic immune cells in the tumor microenvironment (TME). While tumor-derived exosomes contribute to immune cell suppression in the TME, information on the effects of PT on exosomes and anti-tumor immune responses in HNSCC is not known.
View Article and Find Full Text PDFTransdermal drug delivery provides convenient and pain-free self-administration for personalized therapy. However, challenges remain in treating acute diseases mainly due to their inability to timely administrate therapeutics and precisely regulate pharmacokinetics within a short time window. Here we report the development of active acoustic metamaterials-driven transdermal drug delivery for rapid and on-demand acute disease management.
View Article and Find Full Text PDFOptimizing drug inhibition of IgE-mediated anaphylaxis in mice.
J Allergy Clin Immunol
February 2022
Background: Administering allergens in increasing doses can temporarily suppress IgE-mediated allergy and anaphylaxis by desensitizing mast cells and basophils; however, allergen administration during desensitization therapy can itself induce allergic responses. Several small molecule drugs and nutraceuticals have been used clinically and experimentally to suppress these allergic responses.
Objectives: This study sought to optimize drug inhibition of IgE-mediated anaphylaxis.
Background: Mast cell and basophil activation by antigen cross-linking of FcεRI-bound IgE is central to allergy pathogenesis. We previously demonstrated global suppression of this process by rapid desensitization with anti-FcεRIα mAbs.
Objectives: We sought to determine whether use of monovalent (mv) anti-FcεRIα mAbs increases desensitization safety without loss of efficacy.