Risk factors for silicotuberculosis among miners: a scoping review.

Background: Miners exposed to silica dust are susceptible to silicotuberculosis (STB) outcome - the development of tuberculosis (TB) in miners with silicosis. STB is an important occupational and public health issue in the twenty-first century. This scoping review aimed to map the risk factors associated with STB.

Identification, Synthesis, and Characterization of N-Formyl Mirabegron: A New Degradation Product Formed by Formic Acid Impurity in Pharmaceutical Excipients.

This study demonstrated the impact of formic acid (FAc), a common reactive impurity in pharmaceutical excipients, on the stability of mirabegron (MB). The investigation of MB-excipient compatibility tests revealed the formation of a new degradation product, FAc-DP, at 0.2% after 7 days of isothermal stress at 55°C.

Being a Pakistani mother in Catalonia: a mixed methods study.

Introduction: In Pakistani migrant families, contextual transformation can affect adult caregivers' parental skills and their ability to exercise positive parenting. We focused on identifying and describing patterns, practices and beliefs about parenting, identifying differential characteristics between the context of origin and the host context, and exploring Pakistani immigrants' use of resources or assets in the area of parenting support.

Methods: Participants consisted of 20 women, established in Catalonia, Spain (<5 years of residence) who have children (at least one of preschool-age).

The path of least resistance: The unusual extradigestive journey of a nasogastric tube following oropharyngeal perforation.

Nasogastric tube placement is frequently performed in various medical settings. While generally deemed safe in patients without risk factors, complications may occur due to malposition, justifying the need of systematic confirmation of position with chest radiographs. We present the case of a critically ill male adult patient for whom the tube position was initially deemed very unusual on postinsertion radiographs, prompting further workup which ultimately confirmed an oropharyngeal perforation with a left parapharyngeal, left visceral, retrotracheal, and right retrodiaphragmatic course, and resulting in a recurrent pneumothorax and empyema treated by surgical decortication.

The distribution of regions of homozygosity (ROH) among consanguineous populations-implications for a routine genetic counseling service.

Regions of homozygosity (ROH) increase the risk of recessive disorders, and guidelines recommend reporting of excessive ROH in prenatal testing. However, ROH are common in populations that practice endogamy or consanguinity, and cutoffs for reporting ROH in such populations may not be evidence-based. We reviewed prenatal testing results (based on cytogenetic microarrays) from 2191 pregnancies in the Jewish and non-Jewish populations of Northern Israel and estimated the prevalence of ROH according to self-reported ethnicity and parental relationships.