Case report: a rare case of Hunter syndrome (type II mucopolysaccharidosis) in a girl.

Background: Hunter syndrome (mucopolysaccharidosis type II) is a recessive X-linked disorder due to mutations in the iduronate 2-sulfatase (IDS) gene. The IDS gene encodes a lysosomal enzyme, iduronate 2-sulfatase. The disease occurs almost exclusively in males.

INFLUENCE OF TESTOSTERONE ON MORPHOLOGICAL CHANGES IN PANCREATIC ISLETS AND LIVER TISSUE OF RATS WITH ALLOXAN-INDUCED DIABETES.

The role of exogenous testosterone (methyltrienolone) in the repair of damaged pancreatic islet and liver cells during alloxan diabetes was studied. Modeling of diabetes was performed through single intraperitoneal injection of Alloxan, with the dose 2 mg per 10 g of body weight. Pancreatic and liver tissues were investigated microscopically using 3-4 µm slices embedded in paraffin and stained with hematoxylin and eosin.

[The hypoxic syndrome in children with cardiomyopathy].

The children with inherited cardiopathy including hypersensitive (n = 85) and dilatation (n=10) cardiopathy as well as cardiopathy under Ehlers-Danlos Syndrome (n = 70) combined with different inherited heart disease were examined to establish signs of hematic and tissue hypoxia. The most typical signs turned out periodic decrease of blood pCO2 with increasing of content of lactate and pyruvate in blood and saliva, multiple caries of teeth and high rate of systemic hypoplasia of enamel of both temporary and permanent teeth. The study established decrease in blood of level of macro-ergic compounds (ATP, ADF AMP) with increasing of excretion calcium and phosphates with urine.

Blood pressure patterns in urban and rural children and adolescents of the Kakheti region (East Georgia).

Research was conducted in urban and rural areas of the city Telavi in 2012-2013. 493 public school pupils aged 6-18 were studied (267-urban resident, 226-rural resident). Results are grouped separately for all (13) aging clusters.

[Tobacco consumption among teenagers of school age in the East Georgian region of Kakheti].

The aim of the article was to study tobacco consumption in the East Georgian region of Kakheti among rural and urban pupils using the anonymous epidemiological questionnaire. The survey was carried out on 412 pupils aged 15-18 years (220 girls and 192 boys). Research showed that 98,3% of teenagers are informed about tobacco harm; 71,3% of respondents did not know of the dangers of passive smoking.