Radioisotopic determination of cerebrospinal fluid (CSF) folic acid and vitamin B12 in neurological disorders.

In a total of 55 samples of cerebrospinal fluid (CSF) and an equal number of serum samples obtained from 45 patients with neurological disorders and 10 controls, folic acid and vitamin B12 were measured. A radioisotopic assay method was used. A significant decrease of CSF folic acid was noted in the group with cerebral tumors.

Cerebrospinal fluid cyclic adenosine 3',5'-monophosphate in cases of severe cerebral ischemia and meningitis.

The concentration of cyclic adenosine 3',5'-monophosphate (cAMP) in cerebrospinal fluid was measured in 45 samples from 45 subjects, one sample per subject. 12 of the studied persons were (control group) neurologically normal, 11 were suffering from acute cerebral ischemia with deep coma, and 22 from meningitis of different types. The mean value obtained in the control group was 21.

Serum vitamin B12 and folic acid levels in hyperthyroidism.

Serum vitamin B12 and folic acid levels were measured in 48 hyperthyroid patients and in a group of euthyroid controls. The levels of vitamin B12 ranged from 120-900 pg/ml with a mean of 429.3 +/- 30.