Publications by authors named "M Kerscher"
Objectification of Skin Firmness: In Vivo Evaluation of 300 Women in Relation to Age.
J Cosmet Dermatol
January 2025
Background: The concept of "skin quality" (SQ) has gained widespread attention, with a recent international consensus defining it and outlining four "emergent perceptual categories" (EPCs), each accompanied by specific parameters and associated measurement methods. No research has confirmed whether the parameters linked to these EPCs vary objectively with age. This gap in data is significant, as understanding how these parameters correlate with age could be essential for creating an objective, age-adjusted classification of SQ.
View Article and Find Full Text PDFPd(0)/Pd(II) Electromerism Triggered by Lewis Base Coordination to a Redox-Active Silicon Z-Type Ligand.
Angew Chem Int Ed Engl
December 2024
Electromerism (aka. valence tautomerism) corresponds to the switching of electronic distributions between redox-active ligands and central elements. While this phenomenon is well established for several transition metals, the Pd(0)/Pd(II) couple could not yet be involved due to the high energy of the Pd(0) state.
View Article and Find Full Text PDFBackground: Two randomized, double-blind, placebo-controlled, Phase III studies of incobotulinumtoxinA for treating upper facial lines (UFL; combination of glabellar frown lines [GFL], horizontal forehead lines [HFL] and lateral canthal lines [LCL]) were conducted in the US (ULTRA I: NCT04594213) and Germany (ULTRA II: NCT04622254).
Objectives: To evaluate safety and efficacy of simultaneous intramuscular injections for UFL. Longer-term safety and efficacy were assessed in open-label extension periods (OLEX).
Article Synopsis
- Telangiectasia is a key feature of rosacea, necessitating effective treatment and standardized assessment tools for clinical evaluations.
- The study aimed to create and validate the TRoSA scale, a five-point photonumeric system to evaluate telangiectasia severity in rosacea patients, using feedback from 16 experts and 50 patient images.
- Results showed that the TRoSA scale has high interrater and intrarater reliability, making it a reliable tool for consistent clinical assessments and treatment evaluations in rosacea.
Background: Aesthetic medicine has traditionally relied on clinical scales for the objective assessment of baseline appearance and treatment outcomes. However, the scales focus on limited aesthetic areas mostly and subjective interpretation inherent in these scales can lead to variability, which undermines standardization efforts.
Objective: The consensus meeting aimed to establish guidelines for AI application in aesthetic medicine.