Publications by authors named "M Keles"
Within- and between-subject biological variation data for whole blood HbA from 38 apparently healthy Turkish subjects.
Scand J Clin Lab Invest
December 2024
Article Synopsis
- HbA is crucial for diagnosing and treating diabetes, serving as a key biomarker for monitoring blood sugar levels and predicting vascular complications.
- The study measured biological variation (BV) in HbA by collecting and analyzing blood samples from 38 healthy individuals over ten weeks using advanced statistical methods.
- Findings showed a within-subject BV of 2.9% and a between-subject BV of 7.9%, suggesting that the reference change value is more reliable for interpreting HbA1c than standard population references.
Article Synopsis
- * About 9.8% of the patients died during hospitalization, with older individuals and those with preexisting kidney issues showing higher mortality rates due to severe injuries and complications.
- * Key factors influencing mortality included age, injury severity, shock, and certain elevated lab values, highlighting the need for better disaster preparedness and health care improvements for future events.
Article Synopsis
- Millions are affected by natural disasters annually, leading to serious medical issues like crush syndrome, which often results in acute kidney injury tied to high mortality rates.
- This study analyzed data from 1024 patients with crush syndrome after the February 2023 earthquakes in Kahramanmaras, focusing on their treatment and outcomes in Turkish hospitals.
- The findings revealed high rates of acute kidney injury and hemodialysis treatment, with a 9.8% in-hospital mortality rate, highlighting the urgent need for improved emergency response training and protocols for managing kidney health in disaster scenarios.
Endothelial derived, secreted long non-coding RNAs and aggravate cardiac remodeling.
Mol Ther Nucleic Acids
September 2024
Article Synopsis
- Pathological cardiac remodeling can lead to heart failure, and the study focused on two long non-coding RNAs (lncRNAs) that are upregulated in failing hearts.
- Overexpressing these lncRNAs in mice worsened heart dysfunction and increased hypertrophy and fibrosis in response to pressure overload.
- Knocking out these lncRNAs reduced heart damage and improved blood vessel growth but also led to sudden death in some mice, highlighting their complex role in heart failure and potential as therapeutic targets.