Publications by authors named "M Keese"
Article Synopsis
- Chemotherapy effectively kills rapidly dividing cancer cells but struggles to eliminate slower-dividing cancer stem cells and dormant cells, leading to reduced effectiveness with prolonged treatment.
- A study was conducted using a specific cancer cell model to analyze how chemotherapy affects gene expression related to cancer cell survival and dormancy by comparing treated and untreated cells in mice.
- Findings revealed that chemotherapy alters the expression of genes associated with cancer cell dormancy and survival, while downregulating pathways that initiate cell death, suggesting new targets for improving treatment outcomes against drug resistance.
Article Synopsis
- The study investigates the link between the C677T polymorphism of the methylenetetrahydrofolate reductase gene and the risk of colorectal polyps in the Azerbaijani population, aiming to enhance personalized medicine for CRC prevention.
- It compared 125 patients with colon polyps to 155 healthy controls, analyzing DNA through specific laboratory techniques.
- Results showed no significant associations between the gene variants and disease risk, indicating that factors like age, sex, smoking, and alcohol use did not differ significantly between the patient and control groups.
Article Synopsis
- Adipose-derived stem cells (ASCs) are being tested in clinical trials as a treatment for peripheral artery disease (PAD), focusing on their impact on hypoxic endothelial cells and stress responses in a mouse model.* -
- The study found that ASCs improved cell survival under hypoxic conditions by reducing endoplasmic reticulum (ER) stress and promoting muscle recovery in mice with induced ischemia.* -
- The treatment with ASCs showed decreased muscle necrosis, inflammation, and improved enzyme levels, suggesting that ASCs could be a promising alternative therapy for PAD patients unable to undergo traditional procedures.*
Objective: The use of medical compression stockings (MCS) in patients with peripheral arterial disease (PAD) and diabetes is the subject of an ongoing critical debate. While reducing leg edema of various origins by improving venous back flow, there is a concern about additional arterial flow obstruction when compression therapy is applied in pre-existing PAD. The aim of this study is to obtain further information on the use of class I MCS in patients with advanced PAD and to evaluate the framework conditions for a safe application.
View Article and Find Full Text PDFBackground: Postthrombotic syndrome (PTS) has a major impact on the quality of life after deep venous thrombosis (DVT). From clinical practice and related trials, anticoagulants show potential for reducing the occurrence and alleviating the symptoms of PTS.
Methods: A systematic review and Bayesian network meta-analysis (NMA) were conducted by combing the literature from the databases of MEDLINE, Embase, Web of Science, Cochrane Libraries, and ClinicalTrials, through a variety of medical subject headings (Mesh) and PTS keywords.