Publications by authors named "M Keara Boss"
Evaluating the local immune microenvironment of the canine nasal cavity can be important for investigating normal tissue health and disease conditions, particularly those associated with local inflammation. We have optimized a technique to evaluate the local nasal immune microenvironment of dogs via serial nasal lavage. Briefly, with dogs under anesthesia and positioned in sternal recumbency, prewarmed sterile saline is flushed into the affected nostril using a flexible soft rubber catheter.
View Article and Find Full Text PDFThe dynamic susceptibility contrast (DSC) MRI measures of relative cerebral blood volume (rCBV) play a central role in monitoring therapeutic response and disease progression in patients with gliomas. Previous investigations have demonstrated promise of using rCBV in classifying tumor grade, elucidating tumor viability after therapy, and differentiating pseudoprogression and pseudoresponse. However, the quantification and reproducibility of rCBV measurements across patients, devices, and software remain a critical barrier to routine or clinical trial use of longitudinal DSC MRI in patients with gliomas.
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- * Researchers looked at the effects of GLP-1R agonists on the HPA axis and cortisol levels in individuals with varying responses to the treatment using advanced imaging techniques.
- * Results showed that pituitary GLP-1R expression was present in all participants, and while there were some differences by sex, the study concluded that HPA axis stimulation doesn't explain why some people poorly respond to GLP-1R agonists, suggesting the need for more research.
The objective of this study is describe outcome and toxicity for dogs with oral tumors, specifically oral malignant melanoma (OMM), squamous cell carcinoma (SCC), and soft tissue sarcoma (STS) after stereotactic body radiation therapy (SBRT). A single institution retrospective study was conducted. Outcomes were analyzed using Kaplan-Meier analysis and Cox proportional hazard analysis.
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- The study compares the effectiveness of Ga-NODAGA-exendin-4 PET/CT to traditional imaging methods for locating insulinomas, a type of tumor that causes low blood sugar.
- Exendin PET/CT showed a significantly higher diagnostic accuracy (94.4%) compared to DOTA-SSA PET/CT (64.8%), CT/MRI (83.3%), and endoscopic ultrasound (82.8%).
- The findings suggest that exendin PET/CT offers better image quality and consistency among observers, making it a valuable tool for the preoperative assessment of insulinomas.