Publications by authors named "M Kawazoe"
Altered gut microbiota is linked to systemic lupus erythematosus (SLE), but its association with disease development, disease activity, and post-intervention changes remains unclear. We compared new-onset SLE (NOSLE, n = 25), SLE in remission (RemSLE, n = 30), and healthy controls (HC, n = 30) cross-sectionally and conducted the first longitudinal analysis of NOSLE patients (n = 22) from pre-intervention to remission over 12 months. Significant β-diversity differences were observed in both NOSLE and RemSLE compared to HC, but not between NOSLE and RemSLE.
View Article and Find Full Text PDFThe effect of self-measurement of blood pressure (BP) at home (home BP measurement, HBPM) has been evaluated over the past decade. This meta-analysis included the latest studies to determine whether HBPM reduced BP (PROSPERO ID: CRD42023442225). PubMed, Cochrane Library Database, and IchuShi-Web were searched for randomized controlled trials after the year 2000 which demonstrated the effect of HBPM on BP change compared with usual care (UC).
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- The Wnt/β-catenin signaling pathway is implicated in glucocorticoid-induced osteoporosis (GIOP), and previous studies suggested that inhibiting sclerostin could provide a treatment option.
- The study aimed to evaluate the effectiveness of romosozumab (ROMO), compared to denosumab (DMAb) and bisphosphonates (BP), in increasing bone mineral density (BMD) in patients with rheumatic diseases undergoing glucocorticoid therapy.
- Results showed that ROMO significantly improved lumbar spine BMD after 12 months, indicating that it is a promising treatment for patients with GIOP.
Article Synopsis
- The study aimed to assess the positive predictive value (PPV) of clinical diagnoses of multiple system atrophy (MSA) over two time periods, comparing data from 2008-2017 to 2018-2022, hypothesizing that advancements in diagnostic tools such as brain MRI would improve accuracy.
- Among 321 patients diagnosed with MSA, the overall PPV increased from 63% to 78% between the two evaluated periods, with brain MRI usage rising significantly, indicating a strong correlation between MRI use and higher PPV for MSA cases.
- The results also showed that while the PPV for the cerebellar type of MSA remained stable, the PP
Japanese guidelines recommend angiotensin II receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACEIs) as first-line therapy in hypertensive patients with chronic kidney disease (CKD) and proteinuria, but calcium channel blockers in patients with stage G4-5 CKD aged ≥75 years; however, the implementation of these guidelines in clinical practice is unclear. We investigated the actual use of these agents in this patient population. We conducted a cross-sectional study using the DeSC database, which includes anonymous information from various health insurance systems in Japan.
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