Publications by authors named "M Kawakita"
Article Synopsis
- Upstaging to pT3a after partial nephrectomy for cT1 renal cell carcinoma (RCC) is uncommon, occurring in 3.6% of cT1a and 19% of cT1b patients within a study of 389 cases from 2011-2022.
- The median tumor size for upstaged cases was 43 mm, and during a 59-month follow-up, there were six recurrence events, highlighting a significant risk for those with Fuhrman grade ≥3.
- Five-year survival rates were reported as 75.7% for metastasis-free survival, 96.2% for cancer-specific survival, and 88.1% overall, indicating
Dose compliance of estramustine phosphate in neoadjuvant chemohormonal therapy combined with degarelix acetate predicts the biochemical recurrence in patients with very high-risk prostate cancer who underwent robot-assisted radical prostatectomy.
Int J Urol
December 2024
Article Synopsis
- The study aimed to assess the safety and effectiveness of neoadjuvant treatment with degarelix acetate and low-dose estramustine phosphate in men with high-/very high-risk prostate cancer before surgery.
- A total of 187 patients participated, with 140 undergoing surgery after receiving 6 months of the treatment, highlighting adverse events, surgical outcomes, and rates of biochemical recurrence.
- Results showed that patients with very high-risk status and those who reduced the dose of estramustine phosphate had lower rates of biochemical recurrence, indicating that maintaining dose compliance may impact survival outcomes in this group.
Article Synopsis
- The study aimed to evaluate the safety of preserving the urethra during radical cystectomy by using frozen section analysis (FSA) to check for recurrence of urothelial carcinoma.
- Researchers analyzed 77 male patients who underwent FSA; those with abnormal results had their urethra removed, while those with normal results had it preserved.
- The findings showed a 100% negative predictive value for FSA, and after an average follow-up of 38 months, no urethral recurrences were detected, highlighting the potential usefulness of FSA in guiding treatment decisions.
Considering the structure of the bacterial GH15 family glucoamylase (GA), Thermoplasma trehalase Tvn1315 may be composed of a β-sandwich domain (BD) and a catalytic domain (CD). Tvn1315 BD weakly binds to insoluble β-glucans, such as cellulose, and helps fold CD. To determine how aromatic residues contribute to proper folding and enzyme activity, we performed alanine scanning for 32 aromatic residues in the BD.
View Article and Find Full Text PDFBackground: This study aimed to compare the efficacy of robot-assisted partial nephrectomy for completely endophytic renal tumors with the reported outcomes of conventional laparoscopic partial nephrectomy and investigate the transition of renal function after robot-assisted partial nephrectomy.
Methods: We conducted a prospective, multicenter, single-arm, open-label trial across 17 academic centers in Japan. Patients with endophytic renal tumors classified as cT1, cN0, cM0 were included and underwent robot-assisted partial nephrectomy.