Risk of Cardiovascular Diseases After Nonfocal Transient Neurologic Attacks in the Elderly: The Rotterdam Study.

Background And Objectives: Nonfocal transient neurologic attacks (TNA) have been suggested to increase the risk of stroke, yet the optimal clinical approach of these attacks remains uncertain. We determined whether people who have a nonfocal TNA are at an increased risk of subsequent cardiovascular disease (CVD), akin to the known increased risk of stroke following transient ischemic attack (TIA).

Methods: Within a population-based cohort study among Dutch participants aged 45 years or older, we selected participants who had first-ever TNA, defined as an attack of sudden neurologic symptoms resolving within 24 hours without clear evidence for an alternative diagnosis, during follow-up between 1990 and 2020.

Integration of genetic testing into diagnostic pathways for cardiomyopathies: a clinical consensus statement by the ESC Council on Cardiovascular Genomics.

In the modern era, cardiologists managing patients and families with cardiomyopathies need to be familiar with every stage of the diagnostic pathway from clinical phenotyping to the prescription and interpretation of genetic tests. This clinical consensus statement from the ESC Council for Cardiovascular Genomics aims to promote the integration of genetic testing into routine cardiac care of patients with cardiomyopathies, as recommended in the 2023 ESC guidelines for cardiomyopathies. The document describes the types of genetic tests currently available and provides advice on their prescription and for counselling after the return of genetic findings, including the approach in patients and families with variants of unknown significance.

Baroreflex Sensitivity and Long-Term Dementia Risk in Older Adults.

Background: Increased blood pressure (BP) variability is linked to dementia risk, but the relationship between baroreflex sensitivity (BRS), a fundamental mechanism for maintaining stable BP, and dementia risk is undetermined.

Methods: We tested the hypothesis that impaired BRS is associated with increased dementia risk in 1819 older adults (63% women; age, 71.0±6.

Associations between subclinical thyroid dysfunction and cardiovascular risk factors according to age and sex.

Context: Subclinical thyroid dysfunction (ScTD) comprising subclinical hypothyroidism (SHypo) and subclinical hyperthyroidism (SHyper) has been associated with increased risk for cardiovascular events.

Objective: To assess associations between ScTD and cardiovascular risk factors (cvRFs) according to age and sex.

Design And Setting: Pooled individual participant data analysis of large prospective cohort studies from the Thyroid Studies Collaboration.