Publications by authors named "M Kavkova"
Article Synopsis
- Mammals have different types of teeth (heterodonty) with simpler teeth in the front and more complex ones in the back, and this study looks at the genes involved in their early development.
- Researchers analyzed gene expression patterns in the lower jaw of mice at two early development stages, finding significant differences in signaling molecules (like BMP and FGF) between the front and back regions of the jaw.
- The study highlights the role of the SATB2 gene in developing incisor teeth and its surprising expression near molars, indicating that gene functions can vary significantly depending on the jaw's location.
Article Synopsis
- This study focuses on Xenopus laevis, an important model organism in developmental biology, specifically regarding its late developmental stages, which are often underrepresented in research.
- Researchers used micro-computed tomography (micro-CT) to create detailed 3D models of Xenopus at various stages from tadpoles to adults, highlighting morphological changes and structures such as the skeleton, teeth, and organs.
- The resulting high-resolution dataset is a valuable resource for future studies in vertebrate development, with potential applications in virtual reality, 3D printing, and educational initiatives.
The Hindbrain Choroid Plexus is a complex, cerebrospinal fluid-secreting tissue that projects into the 4th vertebrate brain ventricle. Despite its irreplaceability in the development and homeostasis of the entire central nervous system, the research of Hindbrain Choroid Plexus and other Choroid Plexuses has been neglected by neuroscientists for decades. One of the obstacles is the lack of tools that describe the complex shape of the Hindbrain Choroid Plexus in the context of brain ventricles.
View Article and Find Full Text PDFMotor neuron (MN) development and nerve regeneration requires orchestrated action of a vast number of molecules. Here, we identify SorCS2 as a progranulin (PGRN) receptor that is required for MN diversification and axon outgrowth in zebrafish and mice. In zebrafish, SorCS2 knockdown also affects neuromuscular junction morphology and fish motility.
View Article and Find Full Text PDFPrimary cilia are cellular surface projections enriched in receptors and signaling molecules, acting as signaling hubs that respond to stimuli. Malfunctions in primary cilia have been linked to human diseases, including retinopathies and ocular defects. Here, we focus on TMEM107, a protein localized to the transition zone of primary cilia.
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