Publications by authors named "M Kaunisto"
Background: Surgical nerve injuries lead to persistent neuropathic pain (NP) in up to 30% of patients. Among many other factors, polymorphisms in the human leukocyte antigen (HLA) genes have been suggested to contribute to the development of neuropathic pain.
Methods: We performed a genetic association analysis of HLA class I and class II alleles in women who had been operated on for breast cancer.
Article Synopsis
- Science communication is really important because people remember exciting stories better than boring facts.
- The EU-LIFE Science Communications Working Group created a training course to help early-career researchers learn to tell their stories effectively.
- This training has already helped some researchers share their work in science magazines, and now they're adapting it for medical doctors who are getting their PhDs.
Background: Propofol is a widely used intravenous hypnotic. Dosing is based mostly on weight, with great interindividual variation in consumption. Suggested factors affecting propofol requirements include age, sex, ethnicity, anxiety, alcohol consumption, smoking, and concomitant valproate use.
View Article and Find Full Text PDFArticle Synopsis
- The study investigated the genetic and clinical factors that contribute to post-operative nausea and vomiting (PONV), which affects about 30% of patients despite existing preventive measures.
- Conducted at Helsinki University Hospital, the research involved 815 women undergoing breast cancer surgery, examining genetic variants and their association with PONV through a genome-wide association study (GWAS).
- Results revealed that 35% experienced PONV post-surgery, with significant predictors identified, including age, anesthesia status, and previous history of nausea; the GWAS found six genetic variants potentially linked to PONV.