Associations Between State Laws Regulating Minors' Access to Confidential Sexual Health Services and Lifetime HIV Testing Among U.S. Male High School Students.

Confidentiality concerns are a well-established barrier to sexual health services for adolescents. These barriers are likely even greater for young men who have sex with men (YMSM), who often experience stigma at multiple levels. This study examined the relationship between state laws regulating minors' access to confidential sexual health services, sexual behavior, and lifetime HIV testing among a large, representative sample of sexually active male high school students from the 2019 state-level Youth Risk Behavior Surveillance System (23 states; N = 17,509).

Dysfunction of exhausted T cells is enforced by MCT11-mediated lactate metabolism.

CD8 T cells are critical mediators of antitumor immunity but differentiate into a dysfunctional state, known as T cell exhaustion, after persistent T cell receptor stimulation in the tumor microenvironment (TME). Exhausted T (T) cells are characterized by upregulation of coinhibitory molecules and reduced polyfunctionality. T cells in the TME experience an immunosuppressive metabolic environment via reduced levels of nutrients and oxygen and a buildup of lactic acid.

Driving Under the Influence of Alcohol and Cannabis by Sexual Identity, Race, Ethnicity, and Gender: A Nationwide Analysis Using the 2016 to 2019 National Survey on Drug Use and Health.

Background: Sexual minority populations experience higher rates of substance use and related problems, but little is known about their specific involvement in driving under the influence (DUI) of alcohol (DUIA) and cannabis (DUIC) incidents.

Methods: Using data from the 2016 to 2019 National Survey on Drug Use and Health, we used logistic regression models to estimate the interactive effects of sexual identity, race/ethnicity, and gender on past-year DUIA among adults who used alcohol and DUIC among adults who used cannabis, accounting for covariates. Using model estimates and linear combinations, we calculated the predicted probabilities of each outcome and compared sexual identity differences within and across race/ethnicity and gender.