Amygdala Structure and Function: Association With Transdiagnostic Trauma Severity in Anxiety and Mood Disorder Patients.

Reductions in both the size of the amygdala and functional activity during emotional processing have been independently associated with trauma exposure and severity, raising the question of whether reduced volume prompts reduced functional activation. In this multimodal assessment, the relationship between amygdala structure and function was investigated in mood and anxiety patients to determine their covariation and their relationship to trauma magnitude. Overall, amygdala volume and functional emotional reactivity were unrelated, with smaller volumes and reduced emotional reactivity each independently predicting trauma magnitude for women, and mediation analysis did not support a hypothesis that the relationship between reduced functional activity and trauma severity depends on amygdala volume.

A Benchmark, Expand, and Calibration (BenchExCal) Trial Emulation Approach for Using Real-World Evidence to Support Indication Expansions: Design and Process for a Planned Empirical Evaluation.

Real-world evidence involving healthcare database studies is well established for making causal inferences in post-market drug safety studies and methods, data, and research infrastructure for evaluating effectiveness have advanced in recent years. The rapidly expanding field of etiologic research using insurance claims and electronic health records databases is being evaluated for supporting effectiveness claims. One such use case to support regulatory decision-making on effectiveness is for expanding indications beyond existing effectiveness claims.

Measurement of the Branching Fraction Ratios R(D^{+}) and R(D^{*+}) Using Muonic τ Decays.

The branching fraction ratios of B[over ¯]^{0}→D^{+}τ^{-}ν[over ¯]_{τ} and B[over ¯]^{0}→D^{*+}τ^{-}ν[over ¯]_{τ} decays are measured with respect to their muonic counterparts, using a data sample corresponding to an integrated luminosity of 2.0  fb^{-1} collected by the LHCb experiment in proton-proton collisions at sqrt[s]=13  TeV. The reconstructed final states are formed by combining D^{+} mesons with τ^{-}→μ^{-}ν[over ¯]_{μ}ν_{τ} candidates, where the D^{+} is reconstructed via the D^{+}→K^{-}π^{+}π^{+} decay.

Type of Social Support for Smoking Cessation Among Low-Income Postpartum Women.

Background: Efficacious programs to sustain smoking cessation are limited for postpartum women, particularly for those who are low-income. Social support may help enhance cessation efforts. However, the specific types of support potentially associated with cessation success are not well evaluated.

Observation of Exotic J/ψϕ Resonant Structure in Diffractive Processes in Proton-Proton Collisions.

The first study of J/ψϕ production in diffractive processes in proton-proton collisions is presented. The study is based on an LHCb dataset recorded at center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 5  fb^{-1}. The data disfavor a nonresonant J/ψϕ production but are consistent with a resonant model including several resonant states observed previously only in B^{+}→J/ψϕK^{+} decays.