Efficacy of a retinoid complex plus anti-inflammatory component cream alone or in combination with prebiotic food supplement in adult acne: A randomized, assessor-blinded, parallel-group, multicenter trial on 184 women.

Background: Adult female acne (AFA) nowadays is a very common skin condition affecting mainly women aged between 25 and 40. The treatment of AFA could be challenging.

Study Aim: We evaluate and compare the efficacy and tolerability of a cream formulation containing two retinoid molecules (hydroxypinacolone/retinyl palmitate) combined with Iris Florentina root extract and a complex of three oligopeptides (C) applied twice a day (morning and evening) alone or in combination (C + O) with a food supplement containing a mixture of prebiotic molecules (FOS&GOS) zinc, lactoferrin, and niacinamide.

Perforator-based forearm island flap.

Reconstruction of soft tissue defects of the hand with exposed tendons, nerves, joints and bones could be quite a challenge for the surgeon. Only adequate coverage can save their functions. In our case we present a patient with adduction contracture of the right thumb after II degree burns, treated with perforator-based forearm flap.

Neurocutaneous metacarpal flaps.

The article describes the possibility of covering large skin defects of the fingers by the use of fasciocutaneous flap from the back of the hand. It is pedicled on a sensory nerve branch and its paraneural tissue. The flap relies on blood supply from the constant para- and intraneural vascular network which gives perforator branches towards the overlying skin as well as on the constant anastomoses between the dorsal and volar arterial pool.