Pitfalls in the analysis conditions of canine brain perfusion computed tomography.

This study aimed to investigate the impact of selected analysis conditions on blood flow values and color maps in canine brain perfusion computed tomography (PCT) and to propose optimal analysis conditions. Dynamic computed tomography imaging was performed on six beagle dogs. Color maps were generated using a combination of analysis algorithms (box-modulation transfer function (Box-MTF) and singular value deconvolution plus (SVD+) methods), slice thicknesses (4.

Exercise-induced methylation of the Serhl2 promoter and implication for lipid metabolism in rat skeletal muscle.

Objectives: Environmental factors such as physical activity induce epigenetic modifications, with exercise-responsive DNA methylation changes occurring in skeletal muscle. To determine the skeletal muscle DNA methylation signature of endurance swim training, we used whole-genome methylated DNA immunoprecipitation (MeDIP) sequencing.

Methods: We utilized endurance-trained rats, cultured L6 myotubes, and human skeletal muscle cells, employing MeDIP sequencing, gene silencing, and palmitate oxidation assays.

Seroprevalence in Rheumatoid Arthritis Patients with Interstitial Lung Disease.

Background: Rheumatoid arthritis (RA) is complicated with interstitial lung disease (ILD). Gastroesophageal reflux disease is prevented by infection and is a predisposing factor for idiopathic pulmonary fibrosis. However, the prevalence of infection in RA patients with ILD has not been sufficiently investigated.

Reduction of urinary felinine in domestic cats with renal diseases leads to decreased catty odor.

Cats with progressive renal diseases often exhibit a weakened urinary odor, in contrast to normal cat urine which emits odorants with catty odor, such as 3-mercapto-3-methyl-1-butanol, 3-mercapto-3-methylbutyl formate, 3-methyl-3-methylthio-1-butanol, and 3-methyl-3-(2-methyldisulfanyl)-1-butanol. Felinine, an amino acid, is a precursor of these odorants and metabolized from its precursor, 3-methylbutanol glutathione (MBG), via 3-methylbutanol-cysteinylglycine (MBCG). While previous studies have reported felinine excretion in normal cats, its levels in cats with renal diseases remain unclear.

Canine regional gastric blood flow measurement using perfusion computed tomography.

This study aimed to determine the feasibility of using perfusion computed tomography (CT) to assess blood flow in different regions of the stomach in dogs. Dynamic perfusion CT scans were conducted on five beagle dogs, and blood flow analysis was performed using the maximum slope and Patlak plot methods. The findings revealed significant variations in blood flow among the fundus, body, and pylorus of the stomach.