[Pathways from initial symptoms to psychiatric treatment in patients with schizophrenia].

Early intervention is essential for improving the long-term prognosis of schizophrenic patients. With the objective of contributing to early treatment in communities in the future, we retrospectively investigated patient data, including the pathway to psychiatric care, the course prior to consultation, and initial symptoms. An interview survey was conducted involving a total of 125 patients receiving treatment for a diagnosis of schizophrenia and 74 family members using two questionnaire sheets to collect data on the pathway to psychiatric care, age at onset, time between onset and the initiation of treatment, initial symptoms, and the necessary information.

[Effect of ultraviolet-B irradiation pretreatment on a second-set rejection model of orthotopic corneal grafts].

Purpose: To investigate the effect of ultraviolet-B irradiation (UV-B) on the donor cornea in a second-set rejection model of rat orthotopic corneal transplantation.

Materials And Methods: Three patterns of fully mismatched allogeneic bilateral orthotopic corneal transplantations (DA to AO) after 10-week interval were studied: Untreated primary corneal grafts into the right eyes followed by untreated secondary grafts into the left eyes, UV-B treated primary corneal grafts into the right eyes followed by untreated secondary grafts into the left eyes, and untreated primary corneal grafts into the right eyes followed by UV-B treated secondary grafts into the left eyes.

Results: The rejection of untreated secondary grafts was hastened in recipients who had previously rejected untreated primary grafts (p = 0.

Familial case of keratoconus with corneal granular dystrophy.

A family with keratoconus combined with corneal granular dystrophy is reported. The patients are a mother and her two sons. The mother and her elder son have both keratoconus and corneal granular dystrophy; the younger son has keratoconus.

[A familial case of keratoconus with corneal granular dystrophy].

We report a familial case of keratoconus with corneal granular dystrophy. The mother and first son have both keratoconus and corneal granular dystrophy and the second son has keratoconus alone. The keratoconus in this family is thought to be an autosomal dominant or an X-linked inheritance pattern.

Rare activation of the human c-Ha-ras transgene of mice in hemangioendothelial sarcomas and liver tumors induced by Glu-P-1.

A transgenic mouse (Tg), having the human c-Ha-ras proto-oncogene, has been demonstrated to develop hemangioendothelial sarcomas (HESs) which are associated with the transgene mutation, but not to develop liver tumors. In this study, we examined the effects of 2-amino-6-methyldipyrido [1,2-a:3',2'-d] imidazole (Glu-P-1), a food-borne carcinogen, which has been demonstrated to induce HESs and liver tumors in CDF1 mice, on Tg mice. Chronic administration of 0.