Publications by authors named "M Katagiri"
Article Synopsis
- Clonal hematopoiesis of indeterminate potential (CHIP) is shown to worsen outcomes in patients with nonischemic dilated cardiomyopathy (DCM) despite being well-known for its negative impacts on atherosclerotic disease.
- Researchers analyzed 198 DCM patients using advanced genetic sequencing to find both germline mutations linked to cardiomyopathy and somatic mutations in CHIP driver genes, discovering 25 CHIP mutations in 22 patients.
- The study concluded that CHIP is an independent risk factor for cardiac issues in DCM, contributing to worsened heart function and structural damage, and that genetic mutations can help predict patient prognosis.
Background: The heart comprises many types of cells such as cardiomyocytes, endothelial cells (ECs), fibroblasts, smooth muscle cells, pericytes, and blood cells. Every cell type responds to various stressors (eg, hemodynamic overload and ischemia) and changes its properties and interrelationships among cells. To date, heart failure research has focused mainly on cardiomyocytes; however, other types of cells and their cell-to-cell interactions might also be important in the pathogenesis of heart failure.
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