Publications by authors named "M Kashii"
Surgery is often the treatment of choice for lumbar disc herniation (LDH) with severe leg pain. This study aimed to investigate the efficacy of Condoliase chemonucleolysis (CC) in patients who were nonambulatory because of severe leg pain. A total of 58 patients who underwent CC for conservative treatment-resistant LDH were included in this study.
View Article and Find Full Text PDFPurpose: To evaluate the impact of prior teriparatide (TPTD) treatment on the effectiveness of romosozumab (ROMO) in postmenopausal osteoporosis.
Methods: In this retrospective, case-controlled, multicenter study, 323 postmenopausal patients were initiated ROMO. Of these, 275 were treatment-naïve, and 48 were switched from TPTD, with uninterrupted ROMO treatment for 12 months.
Article Synopsis
- - The study investigated the effectiveness of condoliase chemonucleolysis (CC) for patients with lumbar disc herniation (LDH), focusing on identifying factors that predict early pain relief after treatment.
- - Out of 52 patients, 75% experienced significant leg pain relief just one day post-treatment, while those with a smaller baseline straight leg raising (SLR) angle were more likely to be early responders.
- - The findings suggest that patients with lower pretreatment SLR angles are more likely to achieve early and sustained relief from leg pain following CC, regardless of the characteristics of their disc herniation.
Unlabelled: The impact of ROMO on the width of anabolic windows and the increase in BMD was reduced in the RA group compared to the non-RA group, and this reduction was associated with correlations to RA-related factors.
Purpose: To investigate the effects of romosozumab (ROMO) in postmenopausal osteoporosis, with and without comorbid rheumatoid arthritis (RA).
Methods: In this retrospective, case-controlled, multicenter study, 171 postmenopausal patients who did not receive oral glucocorticoid, comprising 59 in the RA group and 121 in the non-RA group, received uninterrupted ROMO treatment for 12 months.
Article Synopsis
- Ossification of the posterior longitudinal ligament of the spine (OPLL) is a disease that can cause serious neurological issues, and its causes are not fully understood, particularly in relation to type 2 diabetes and high body mass index (BMI).
- A comprehensive meta-analysis involving 22,016 Japanese individuals identified 14 significant genetic markers linked to OPLL, with 8 being newly discovered, and further analyses pointed to specific genes associated with the disease.
- The research revealed that increased BMI and high bone mineral density could have a causal relationship with OPLL, and different subtypes of the disease were identified, particularly highlighting a strong correlation between BMI and thoracic OPLL.