Publications by authors named "M Kashamuka"
Purpose: The Democratic Republic of Congo has one of the highest burdens of malaria in the world, accounting for 12.3% of malaria cases and 11.6% of malaria deaths.
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- Plasmodium ovale curtisi (Poc) and Plasmodium ovale wallikeri (Pow) are two distinct malaria parasites now recognized in Africa and Asia, previously thought to be one species.
- A genomic study analyzed 25 newly sequenced isolates from Central and East Africa, finding that genetic variations are geographically clustered and predominantly monoclonal.
- Poc exhibits higher genetic diversity than Pow, and both species show evidence of selective pressure on certain genes, indicating their adaptation and resilience despite malaria control efforts.
Hepatitis B virus (HBV) antiviral administration and adherence are essential to reach the World Health Organization's 2030 hepatitis elimination goals. As HBV treatment guidelines are now simplified and expanded, adherence to treatment will be critical, but challenges to adherence are poorly studied. After introducing tenofovir disoproxil fumarate (TDF) monotherapy to expectant mothers with high-risk HBV in Kinshasa, DRC, we conducted semi-structured interviews to understand medication adherence behaviors, to complement pill counts and measurement of TDF metabolite levels.
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- A large genomic study on African malaria isolates was conducted, analyzing 77 samples from Cameroon, the Democratic Republic of the Congo, Nigeria, and Tanzania collected between 2015 and 2021.
- The study found no geographic population structure among the isolates, indicating that they are panmictic and mixing freely across different regions.
- While there were no clear indicators of significant resistance genes, certain erythrocyte invasion ligands and antimalarial resistance markers showed signs of selective pressure, suggesting that the malaria population is recovering from a past decline.
Background: The parasite species Plasmodium ovalecurtisi (P. ovalecurtisi) and Plasmodium ovalewallikeri (P. ovalewallikeri), formerly known as Plasmodium ovale, are endemic across multiple African countries.
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