Eco-friendly and smart spectrophotometric approaches for quality control analysis of one of β-blockers in their dosage.

The pharmaceutical industry's rapid progress has spurred the demand for diverse analysis approaches within quality control laboratories to investigate approved drug combinations. Antihypertensive drugs, especially beta-blockers (BB), represent a significant pharmaceutical group, with increasing consumption. The presented research resolves spectral overlay for important binary combination of Propranolol hydrochloride (PRO) and Hydrochlorothiazide (HCT) which its zero order spectrums exhibit interference with a lack of iso-absorptive points, throughout three proposed approaches: Induced Dual Wavelength (IDW), Absorptivity Factor (α-factor), and Amplitude Factor (P-factor).

Case Series of Primaquine-Induced Haemolytic Events in Controlled Trials with G6PD Screening.

Primaquine for radical cure of malaria poses a potentially life-threatening risk of haemolysis in G6PD-deficient patients. Herein, we review five events of acute haemolytic anaemia following the administration of primaquine in four malaria trials from Indonesia, the Solomon Islands, and Vietnam. Five males aged 9 to 48 years were improperly classified as G6PD-normal by various screening procedures and included as subjects in trials of anti-relapse therapy with daily primaquine.

Management of patients with disk displacement without reduction of the temporomandibular joint by arthrocentesis alone, plus hyaluronic acid or plus platelet-rich plasma.

Background: Disk displacement without reduction (DDwoR) is one of the most common temporomandibular joint disorders (TMDs); it can manifest itself in joint pain and limited mouth opening. Nowadays, many arthrocentesis techniques are used with no consensus on which technique is optimal.

Objectives: The aim of this study was to investigate the efficacy of 3 techniques in the treatment of TMD known as DDwoR and to compare them in order to determine whether one is superior to the others.

Improving Workplace-Based Intervention in Indonesia to Prevent and Control Anemia.

The present study determined female workers' experiences and preferences to improve the workplace anemia prevention program in Indonesia by studying their perception of anemia, as well as its risk factors and control. This qualitative study was conducted using focus group discussions (FGDs) to assess female workers' understanding about anemia and possible improvements for workplace-based intervention in a factory located in East Jakarta, Indonesia. Participants were consisted of 14 FGD groups according to anemia status and potential affecting characteristics, including marital status, ethnicity, religion, and frequency of medical consultations.

Rotaxane-Based Mechanophores Enable Polymers with Mechanically Switchable White Photoluminescence.

Three mechanoresponsive polyurethane elastomers whose blue, green, and orange photoluminescence can be reversibly turned on by mechanical force were prepared and combined to create a blend that exhibits deformation-induced white photoluminescence. The three polyurethanes contain rotaxane-based supramolecular mechanoluminophores based on π-extended pyrene, anthracene, or 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4-pyran (DCM) luminophores, respectively, and 1,4,5,8-naphthalenetetracarboxylic diimide as an electronically matched quencher. Each polymer shows instantly reversible, strain-dependent switching of its photoluminescence intensity when stretched and relaxed, as deformation leads to a spatial separation of the luminophore and quencher.