Publications by authors named "M Karlsen"
Covariate Model Selection Approaches for Population Pharmacokinetics: A Systematic Review of Existing Methods, From SCM to AI.
CPT Pharmacometrics Syst Pharmacol
January 2025
A growing number of covariate modeling methods have been proposed in the field of popPK modeling, but limited information exists on how they all compare. The objective of this study was to perform a systematic review of all popPK covariate modeling methods, focusing on assessing the existing knowledge on their performances. For each method of each article included in this review, evaluation setting, performance metrics along with their associated values, and relative computational times were reported when available.
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- Understanding the risk profile of obstetric complications in pregnancies with fetal major congenital heart defects (MCHDs) is essential for effective counseling and care.
- This cohort study analyzed data from over 534,000 pregnancies in Denmark between 2008 and 2018, focusing on the link between fetal MCHDs and adverse obstetric outcomes like preeclampsia and preterm birth.
- Results showed that pregnancies with fetal MCHDs had a significantly higher rate of adverse outcomes (22.8%) compared to those without MCHDs (9.0%), highlighting the increased risks associated with these conditions.
Online Lifestyle Medicine Continuing Medical Education (CME) Course Completion Predicts Increases in Clinician Knowledge, Confidence, and Practice of Lifestyle Medicine.
Am J Lifestyle Med
November 2024
Despite growing evidence linking lifestyle changes to disease reversal, lifestyle medicine (LM) is not widely practiced. Lack of clinician training and knowledge is cited as a barrier to LM adoption. This study measures changes in LM knowledge, attitudes, confidence, and practice behaviors following completion of a 5.
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