Combinatorial Therapy: Targeting CD133+ Glioma Stem-like Cells with a Polysaccharide-Prodrug Complex Functionalised Gold Nanocages.

Cancer treatments are advancing to harness the body's immune system against tumours, aiming for lasting effects. This progress involves combining potent chemotherapy drugs with immunogens to kill cancer cells and trigger lasting immunity. Developing new prodrugs that integrate both chemotherapy and immune-boosting elements could significantly improve anticancer outcomes by activating multiple mechanisms to kill cancer cells.

Efficacy of oleylphosphocholine in experimental cutaneous leishmaniasis.

Objectives: Cutaneous leishmaniasis (CL) is a neglected tropical disease causing a range of skin lesions for which safe and efficacious drugs are lacking. Oleylphosphocholine (OLPC) is structurally similar to miltefosine and has previously demonstrated potent activity against visceral leishmaniasis. We here present the in vitro and in vivo efficacy of OLPC against CL-causing Leishmania species.

A review of the mineralogical and chemical composition of nanoparticles associated with coal fires.

This review summarizes our current knowledge on the health and environmental impact as well as the mineralogical and geochemical composition of nanoparticles (NPs) associated with coal fires. It will furthermore recommend new sampling and characterization protocols to gain a better understanding of the various types of NPs that are formed either through high-temperature nucleation and alteration processes or via low-temperature dissolution-reprecipitation and weathering processes. Coal fires affect the immediate environment of coal-producing areas and produce positive and negative feedback to climate change through the emission of carbon- and sulfate-bearing gases and aerosols, respectively.

Can we Succeed in the Fight Against SARS-CoV-2 with its Emerging New Variants?

In 2019, the whole world came together to confront a life-threatening virus named SARS-CoV-2, causing COVID-19 illness. The virus infected the human host by attaching to the ACE2 and CD147 receptors in some human cells, resulting in cytokine storm and death. The new variants of the virus that caused concern are Alpha, Beta, Gamma, Delta, and Epsilon, according to the WHO label.

Primary Tooth Decay Prevention Program in Children: Application of Intervention Mapping Approach.

Background: As the most common diseases globally, oral and dental diseases are closely related to people's behavior. The present study is aimed at developing a program to prevent primary teeth decay in children using the intervention mapping approach.

Methods: This study protocol is aimed at using the intervention mapping approach as the planning framework.