Publications by authors named "M Kanerva"
Objective: Substantial rise in the annual incidence of methicillin-resistant Staphylococcus aureus (MRSA) was reported in Southwest Finland (12.4-24.9/100,000 people) between 2007 and 2016.
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- Puumala virus (PUUV) can lead to serious illnesses like Hemorrhagic Fever with Renal Syndrome, but the genetic factors affecting disease severity in humans are not well understood.
- A genome-wide association study using data from 2227 cases helped identify significant associations at the Human Leukocyte Antigen (HLA) locus and the ERAP1 gene, which are important for immune response.
- The study found a specific genetic variant (rs26653) in the ERAP1 gene and identified associations with several HLA alleles that suggest how these genetic factors may influence susceptibility to severe PUUV infections.
Background: After COVID-19 infection, long-term impacts on functioning may occur. We studied the functioning of patients with post-COVID-19 condition (PCC) and compared them to controls without PCC.
Methods: This cross-sectional study consisted of 442 patients with PCC referred to rehabilitation at the Helsinki University Hospital (HUS) Outpatient Clinic for the Long-Term Effects of COVID-19, and 198 controls without PCC.
Background: After COVID-19 infection, 10-20% of patients suffer from varying symptoms lasting more than 12 weeks (Long COVID, LC). Exercise intolerance and fatigue are common in LC. The aim was to measure the maximal exercise capacity of the LC patients with these symptoms and to analyze whether this capacity was related to heart rate (HR) responses at rest and during exercise and recovery, to find out possible sympathetic overactivity, dysautonomia or chronotropic incompetence.
View Article and Find Full Text PDFPuumala orthohantavirus-caused hemorrhagic fever with renal syndrome (PUUV-HFRS) is characterized by strong neutrophil activation. Neutrophils are the most abundant immune cell type in the circulation and are specially equipped to rapidly respond to infections. They are more heterogenous than previously appreciated, with specific neutrophil subsets recently implicated in inflammation and immunosuppression.
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