Unveiling the impact of pipe materials on water hammer in pressure pipelines: an experimental and numerical study.

Water hammer (WH) is a phenomenon characterized by the rapid opening or closing of valves or pumps in pipelines, resulting in a disruptive noise, intense vibrations, and potential damage to pipes, fittings, structures, and even human safety. While WH arresters are commonly employed to mitigate this issue in smaller plumbing systems, alternative solutions are required for larger applications like power plants. Researchers have proposed the utilization of pipe materials with a low modulus of elasticity in areas prone to WH events, as these materials possess the capability to absorb a significant portion of the resulting vibrations.

Immunohistochemical Expression of ROR2 in Gastrointestinal Stromal Tumor.

Background: Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors affecting the digestive tract, comprising approximately 0.1-3% of all gastrointestinal cancers. ROR2, a member of the receptor tyrosine kinase orphan receptor subfamily, functions as a signaling receptor for Wnt ligands.

Light curing infection control barriers: do some types jeopardize the concept of conventional bulk-fill composites?

Background: Using infection control barriers (ICBs) on light curing units (LCUs) became mandatory to achieve proper infection control measures without jeopardizing the integrity of the restorations, especially at deeper layers. This study explored the effect of two ICBs on the irradiance of the LCU, as well as the degree of conversion (DC) and flexural strength (FS) of two types of bulk-fill composites. Water vapor permeability (WVP) of both barriers was also assessed to evaluate the capability of such barriers to prevent transmission of blood and saliva droplets and aerosols.

Trastuzumab Deruxtecan with Nivolumab in HER2-Expressing Metastatic Breast or Urothelial Cancer: Analysis of the Phase Ib DS8201-A-U105 Study.

Purpose: This multicenter phase Ib study investigated trastuzumab deruxtecan (T-DXd) plus nivolumab in patients with HER2-expressing metastatic breast cancer (mBC) and metastatic urothelial cancer (mUC).

Patients And Methods: Part 1 determined the recommended dose for expansion of T-DXd plus nivolumab. Part 2 evaluated efficacy and safety; the primary endpoint was confirmed objective response rate by independent central review.

Does Autophagy have a Role in the Pathogenesis of Pediatric Hepatic Steatosis?

Unlabelled: Hepatic steatosis has become the most common cause of chronic liver disease among children worldwide.  Lipophagy has been considered as a pathway affecting steatosis development and progression.

Objective: this study aimed to evaluate the immunohistochemical expression of Beclin1 and LC3A in pediatric hepatic tissues with steatosis and to correlate their expression with clinicopathological parameters.