Stem Cell Markers LGR5, LGR4 and Their Immediate Signalling Partners are Dysregulated in Preeclampsia.

Leucine-rich repeat-containing G protein-coupled receptors 5/4 (LGR5/LGR4) are critical stem cell markers in epithelial tissues including intestine. They agonise wingless-related integration site (WNT) signalling. Until now, LGR5/LGR4 were uncharacterised in placenta, where analogous functions may exist.

Webcams as Windows to the Mind? A Direct Comparison Between In-Lab and Web-Based Eye-Tracking Methods.

There is a growing interest in the use of webcams to conduct eye-tracking experiments over the internet. We assessed the performance of two webcam-based eye-tracking techniques for behavioral research: manual annotation of webcam videos () and the automated WebGazer eye-tracking algorithm. We compared these methods to a traditional infrared eye-tracker and assessed their performance in both lab and web-based settings.

Number Attraction in Pronoun Production.

Pronoun production involves at least two processes: (i) deciding to refer to a referent with a pronoun instead of a full NP and (ii) determining the pronoun's form. In the present study, we assess whether the second of these processes occurs as a by-product of the first process-namely, does accessing the message-level representation of the referent provide access to the features required to determine pronoun form, meaning that pronouns should be robust to errors, or are pronoun features determined through an agreement operation with the antecedent, in which case they may be susceptible to agreement attraction, similar to subject-verb agreement. Prior lab experiments suggest that pronouns display number attraction at a similar rate to verbs.

Heterojunction semiconductor nanocatalysts as cancer theranostics.

Cancer nanotechnology is a promising area of cross-disciplinary research aiming to develop facile, effective, and noninvasive strategies to improve cancer diagnosis and treatment. Catalytic therapy based on exogenous stimulus-responsive semiconductor nanomaterials has shown its potential to address the challenges under the most global medical needs. Semiconductor nanocatalytic therapy is usually triggered by the catalytic action of hot electrons and holes during local redox reactions within the tumor, which represent the response of nontoxic semiconductor nanocatalysts to pertinent internal or external stimuli.

Disease-modifying rdHSV-CA8* non-opioid analgesic gene therapy treats chronic osteoarthritis pain by activating Kv7 voltage-gated potassium channels.

Chronic pain is common in our population, and most of these patients are inadequately treated, making the development of safer analgesics a high priority. Knee osteoarthritis () is a primary cause of chronic pain and disability worldwide, and lower extremity OA is a major contributor to loss of quality-adjusted life-years. In this study we tested the hypothesis that a novel JDNI8 replication-defective herpes simplex-1 viral vector () incorporating a modified carbonic anhydrase-8 transgene () produces analgesia and treats monoiodoacetate-induced () chronic knee pain due to OA.