Publications by authors named "M Kamprad"
[Palliative Sedation - Despite Guidelines a Difficult Process of Decisions].
Dtsch Med Wochenschr
April 2018
A distinction needs to be made between intermediate and continuous sedation as well as between minimal, moderate and deep sedation. To gain ethical acceptance it is crucial that for palliative sedation (PS) minimally required doses are administered to decrease suffering. Intermittent PS is used for decreasing physical symptoms, whereas deep continuous PS is used to minimize intolerable suffering or psychological symptoms.
View Article and Find Full Text PDFXenograft tumor models are widely studied in cancer research. Our aim was to establish and apply a model for aggressive CD20-positive B-cell non-Hodgkin lymphomas, enabling us to monitor tumor growth and shrinkage in a noninvasive manner. By stably transfecting a luciferase expression vector, we created two bioluminescent human non-Hodgkin lymphoma cell lines, Jeko1(luci) and OCI-Ly3(luci), that are CD20 positive, a prerequisite to studying rituximab, a chimeric anti-CD20 antibody.
View Article and Find Full Text PDFArticle Synopsis
- Epidemiological studies highlight long-term heart risks associated with ionizing radiation, even at moderate doses, prompting this study to focus on specific inflammatory, thrombotic, and fibrotic responses to low-dose irradiation in a mouse model.
- Using hypercholesterolemic ApoE-deficient mice, the researchers assessed changes in heart tissue and plasma samples after total body irradiation at various low doses and dose rates, revealing adaptive late responses such as increased capillary density and shifts in inflammatory markers.
- Findings indicate that while low doses may elicit anti-inflammatory effects, higher doses correlate with pro-inflammatory responses, underscoring the importance of understanding age and dose rate variations to guide future evaluations and interventions related to low-dose radiation exposure.