Inbreeding Depression Manifested in Progeny From Fragmented Populations of the Wind-Pollinated Dioecious Conifer (Pilg.) C. N. Page.

Human activities such as agriculture, urbanization, and logging have caused widespread destruction of forests, leading to forest fragmentation. Fragmentation has been shown to reduce genetic diversity and increase inbreeding in forest populations, potentially leading to inbreeding depression manifested through decreased reproductive success and progeny vigor. The severity of these impacts, however, varies among species and is largely influenced by their mating systems.

Correction: Exome sequencing reveals IFT172 variants in patients with non-syndromic cholestatic liver disease.

[This corrects the article DOI: 10.1371/journal.pone.

Impacts of habitat fragmentation on the genetic diversity of the endangered Guatemalan fir (Abies guatemalensis Rehder).

Abies guatemalensis Rehder, an endangered conifer endemic to Central American highlands, is ecologically vital in upper montane forests. It faces threats from habitat fragmentation, unsustainable logging, and illegal Christmas tree harvesting. While previous genetic studies on mature trees from eighteen populations showed high within-population diversity and limited among-population differentiation, the genetic impact of recent anthropogenic pressures on younger generations has yet to be discovered.

Serum neurofilament light chain in response to probiotics in bi-center, double-blind, randomized, placebo-controlled clinical trial (CleverAge Biota).

Background And Aims: Neurodegenerative disorders affecting the brain and spinal cord are caused by a large number of factors. More recently, imbalances in gut microbiota are found to be one factor linked directly to neurological dysfunction. Probiotics prevent cognitive decline.