Publications by authors named "M Kaloper"

Article Synopsis
  • The aging process involves a gradual decline in bodily functions and an increased risk of diseases, largely due to mitochondrial dysfunction, particularly from the loss of Sirtuin 3 (Sirt3).
  • The study examined how the absence of Sirt3 affects mitochondrial function and cellular aging in mouse embryonic fibroblasts (MEF) when exposed to DNA damage from etoposide.
  • Results showed that while male MEF were relatively resilient to stress without Sirt3, female MEF were significantly more vulnerable, highlighting Sirt3's critical role in sex-specific responses to cellular damage and potential therapeutic targets related to aging.
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Prokaryotic genomic DNA is generally negatively supercoiled in vivo. Many regulatory processes, including the initiation of transcription, are known to depend on the superhelical state of the DNA substrate. The stresses induced within DNA by negative superhelicity can destabilize the DNA duplex at specific sites.

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The Stanford Microarray Database (SMD; http://genome-www.stanford.edu/microarray/) serves as a microarray research database for Stanford investigators and their collaborators.

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The Stanford Microarray Database (SMD) stores raw and normalized data from microarray experiments, and provides web interfaces for researchers to retrieve, analyze and visualize their data. The two immediate goals for SMD are to serve as a storage site for microarray data from ongoing research at Stanford University, and to facilitate the public dissemination of that data once published, or released by the researcher. Of paramount importance is the connection of microarray data with the biological data that pertains to the DNA deposited on the microarray (genes, clones etc.

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The Saccharomyces Genome Database (SGD) stores and organizes information about the nearly 6200 genes in the yeast genome. The information is organized around the 'locus page' and directs users to the detailed information they seek. SGD is endeavoring to integrate the existing information about yeast genes with the large volume of data generated by functional analyses that are beginning to appear in the literature and on web sites.

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