Publications by authors named "M Kalil"
Article Synopsis
- Researchers are exploring new ways to enhance interactions between cells and the extracellular matrix (ECM) to improve kidney organoid development from human pluripotent stem cells (hPSCs).
- They created renal decellularized ECM (dECM) hydrogels from porcine and human kidney tissue, which support more effective kidney differentiation and the formation of blood vessel features in organoids.
- This study establishes a method to generate kidney organoids with vascular-like structures, demonstrating the potential for these improved culture systems in advancing personalized medicine applications.
Article Synopsis
- Massive sequencing technologies can help identify multiple genetic disorders in patients with complex clinical symptoms.
- A patient, linked to a related couple, was assessed for issues like lens displacement and deafness, and initially diagnosed with Classic Homocystinuria.
- Further genetic testing revealed additional rare disorders, leading to a better understanding of his conditions and potential treatment options.
is a gram-positive bacterium and is the etiologic agent of caseous lymphadenitis (CL) in small ruminants. This disease is characterized by the development of encapsulated granulomas in visceral and superficial lymph nodes, and its clinical treatment is refractory to antibiotic therapy. An important virulence factor of the genus is the ability to produce biofilm; however, little is known about the characteristics of the biofilm produced by and its resistance to antimicrobials.
View Article and Find Full Text PDFCaseous lymphadenitis (CLA), an infectious disease caused by Corynebacterium pseudotuberculosis in goats and sheep, is highly prevalent worldwide and is characterized by economic losses in small ruminant production. Currently available techniques for clinical and laboratory diagnosis of the disease lack market availability and/or sensitivity, and therefore, infected animals can remain in the herd, serving as a source of infection for other animals. The present study aimed to verify hematological and clinical biochemistry changes in goats naturally infected by C.
View Article and Find Full Text PDFCaseous lymphadenitis (CLA) is a disease that affects small ruminants, and the best way to prevent its spread on a herd is through immunoprophylaxis. Thus, we aimed to evaluate the MBP:PLD:CP40 fusion protein as a new CLA immunogen. The fusion protein was constructed by combining Corynebacterium pseudotuberculosis PLD and CP40 proteins with maltose-binding protein (MBP) as an intrinsic adjuvant.
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