Network topology mapping of chemical compounds space.

We define bipartite and monopartite relational networks of chemical elements and compounds using two different datasets of inorganic chemical and material compounds, as well as study their topology. We discover that the connectivity between elements and compounds is distributed exponentially for materials, and with a fat tail for chemicals. Compounds networks show similar distribution of degrees, and feature a highly-connected club due to oxygen .

Long-Distance Effects of H-NS Binding in the Control of Expression in the Salmonella SPI1 Locus.

Salmonella enterica serovar Typhimurium utilizes a type three secretion system (T3SS) carried on the Salmonella pathogenicity island 1 (SPI1) to invade intestinal epithelial cells and induce inflammatory diarrhea. HilA activates expression of the T3SS structural genes. Expression of yper nvasion ocus A () is controlled by the transcription factors HilD, HilC, and RtsA, which act in a complex feed-forward regulatory loop.

HilD, HilC, and RtsA Form Homodimers and Heterodimers To Regulate Expression of the Pathogenicity Island I Type III Secretion System.

serovar Typhimurium colonizes and invades host intestinal epithelial cells using the type three secretion system (T3SS) encoded on pathogenicity island 1 (SPI1). The level of SPI1 T3SS gene expression is controlled by the transcriptional activator HilA, encoded on SPI1. Expression of is positively regulated by three homologous transcriptional regulators, HilD, HilC, and RtsA, belonging to the AraC/XylS family.