Publications by authors named "M Kaelin"
Article Synopsis
- - The study aimed to assess improvements in health-related quality of life, as measured by the Short Form-36 (SF-36) scores, for patients in a Swiss Outpatient Parenteral Antimicrobial Therapy (OPAT) program from before discharge to 7-14 days after discharge.
- - It involved a cohort of 33 patients from a public hospital in Switzerland, who completed a shortened version of the SF-36 questionnaire and additional questions on satisfaction at two different times.
- - Results indicated significant improvements in three out of four domains (emotional role, social functioning, emotional well-being) and a high patient satisfaction rate, suggesting OPAT programs positively impact patients' health-related quality of life.
The occurrence of transient culture positivity for (MTB), known as , poses significant challenges in understanding its spectrum and implications. Here, we report a case of transient culture positivity, oscillating between detectable and non-detectable MTB cultures with minimal radiological features and review the literature on this phenomenon. The scarcity of scientific literature on this subject stems from the inherent impossibility of systematically studying mirage de tuberculose.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on the effectiveness of outpatient parenteral antimicrobial therapy (OPAT) and its role in antimicrobial stewardship (AMS) at the University Hospital of Zurich from November 2018 to September 2022.
- It analyzed 303 OPAT assignments, with 260 leading to effective treatment; significant cost savings of approximately 9.8 million CHF were achieved by reducing in-hospital stays, while maintaining patient safety and a 77% clinical cure rate.
- The findings suggest that integrating OPAT within AMS enhances patient care and hospital efficiency, with minimal adverse events and readmissions linked to the treatment.
Infection with Mycobacterium tuberculosis (MTB) remains one of the most important opportunistic infections in people with HIV-1 (PWH). While active Tuberculosis (TB) leads to rapid progression of immunodeficiency in PWH, the interaction between MTB and HIV-1 during the asymptomatic phase of both infections remains poorly understood. In a cohort of individuals with HIV (PWH) with and without suppressed HIV-1 viral load, the transcriptomic profiles of peripheral blood mononuclear cells (PBMC) clustered in individuals infected with Mycobacterium tuberculosis (MTB) compared to carefully matched controls.
View Article and Find Full Text PDFLow secondary attack rate after prolonged exposure to sputum smear positive miliary tuberculosis in a neonatal unit.
Antimicrob Resist Infect Control
December 2022
Background: Several neonatal intensive care units (NICU) have reported exposure to sputum smear positive tuberculosis (TB). NICE guidelines give support regarding investigation and treatment intervention, but not for contact definitions. Data regarding the reliability of any interferon gamma release assay (IGRA) in infants as a screening test for TB infection is scarce.
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