Publications by authors named "M Ka"
Article Synopsis
- Integrins are crucial receptors that help cells stick to their surroundings, and abnormal levels of integrins can lead to cancer progression and spread.
- Integrin alpha-5 (ITGA5), which binds to proteins like fibronectin, was found to be linked with poor survival rates in patients with non-small cell lung cancer (NSCLC).
- Experiments showed that increasing ITGA5 led to larger, more mobile cancer cells, while reducing ITGA5 returned those cells to normal behavior, suggesting that targeting ITGA5 could be a potential treatment strategy for NSCLC.
Introduction: Cardiac rehabilitation is crucial in managing coronary disease, particularly in type 2 diabetes, yet it remains almost non-existent in West Africa.
Objectives: This study aimed to compare the profiles of diabetic and non-diabetic coronary patients undergoing cardiac rehabilitation at the Principal Hospital of Dakar, Senegal.
Methodology: A comparative, descriptive, and analytical study was conducted from January 2019 to December 2022 involving two groups of coronary patients (diabetic and nondiabetic) at the rehabilitation centre.
Background: Venous thromboembolic disease (VTE) comprises deep vein thrombosis (DVT) and pulmonary embolism (PE) and ranks third among cardiovascular pathologies. Despite its growing burden in Africa, epidemiological data on VTE in Senegal is scarce. Conclusion: Venous thromboembolic disease is a prevalent and potentially severe condition, especially among relatively young individuals in our setting.
View Article and Find Full Text PDFBarriers to global engagement for African researchers: A position paper from the Alliance for Medical Research in Africa (AMedRA).
J Glob Health
October 2024
Modelling human diabetes : a glance at maturity onset diabetes of the young.
Front Endocrinol (Lausanne)
October 2024
Diabetes is a complex metabolic disease which most commonly has a polygenic origin; however, in rare cases, diabetes may be monogenic. This is indeed the case in both Maturity Onset Diabetes of the Young (MODY) and neonatal diabetes. These disease subtypes are believed to be simpler than Type 1 (T1D) and Type 2 Diabetes (T2D), which allows for more precise modelling.
View Article and Find Full Text PDF